HIV-1 infection of the kidney: mechanisms and implications. (1st March 2021)

• Record Type: Journal Article
• Authors: Hughes, Kelly; Chang, Jerry; Stadtler, Hannah; Wyatt, Christina; Klotman, Mary; Blasi, Maria
• Is Part Of: AIDS. Volume 35:Number 3(2021)
• Page Start: 359
• Page End: 367
• Publication Date: 2021-03-01
• Subjects: ApoL1 -- HIV-1 -- HIV-associated nephropathy -- kidney disease -- kidney transplantation -- reservoir -- urine; AIDS (Disease) -- Periodicals; Acquired Immunodeficiency Syndrome; AIDS (Disease); Periodicals; Periodicals; 616.9792005
• DOI: 10.1097/QAD.0000000000002753
• Languages: English
• ISSNs: 0269-9370

Abstract

Abstract : People living with HIV are at higher risk for acute and chronic kidney disease compared with uninfected individuals. Kidney disease in this population is multifactorial, with several contributors including HIV infection of kidney cells, chronic inflammation, genetic predisposition, aging, comorbidities, and coinfections. In this review, we provide a summary of recent advancements in the understanding of the mechanisms and implications of HIV infection and kidney disease, with particular focus on the role of direct HIV infection of renal cells.