Does a 2-Day Course of Antibiotics Lower the Incidence of Ventilator-associated Pneumonia in Patients Undergoing Targeted Temperature Management Following Cardiac Arrest?. Issue 2 (4th March 2020)

• Record Type: Journal Article
• Authors: LaFond, Elyse; Zappetti, Dana
• Is Part Of: Clinical pulmonary medicine. Volume 27:Issue 2(2020)
• Page Start: 58
• Page End: 59
• Publication Date: 2020-03-04
• Subjects: Lungs -- Diseases -- Periodicals; 616.24005
• DOI: 10.1097/CPM.0000000000000352
• Languages: English
• ISSNs: 1068-0640

Abstract

Abstract : Synopsis: This double-blind, randomized control trial evaluated the efficacy of a 2-day course of amoxicillin-clavulanate in reducing the incidence of early ventilator-associated pneumonia in patients undergoing targeted temperature management following an out-of-hospital cardiac arrest with initial shockable rhythm. There was a significant reduction in the incidence of early ventilator-associated pneumonia in the treatment group when compared with placebo, but no reduction in ventilator-free days or mortality at day 28. Source: Francois B, Cariou A, Clere-Jehl R, et al. Prevention of early ventilator-associated pneumonia after cardiac arrest. N Engl J Med. 2019;381:1831–1842.