A Multicentered Study on Epidemiologic and Clinical Characteristics of 37 Neonates With Community-acquired COVID-19. Issue 10 (October 2020)

• Record Type: Journal Article
• Authors: Kanburoglu, Mehmet Kenan; Tayman, Cuneyt; Oncel, Mehmet Yekta; Akin, Ilke Mungan; Can, Emrah; Demir, Nihat; Arayici, Sema; Baser, Demet Orhan; Caner, Ibrahim; Memisoglu, Asli; Uygun, Saime Sundus; Akar, Selahattin; Akin, Mustafa Ali; Ataoglu, Emel; Bezirganoglu, Handan; Bilgin, Leyla; Bozdag, Senol; Comert, Serdar; Gurpinar, Resat; Imamoglu, Ebru Yalin; Imdadoglu, Timucin; Narter, Fatma; Ozdemir, Ramazan; Toptan, Handan Hakyemez; Yalinbas, Emine Esin; Yaman, Akan; Erdeve, Omer; Koc, Esin
• Is Part Of: Pediatric infectious disease journal. Volume 39:Issue 10(2020)
• Page Start: e297
• Page End: e302
• Publication Date: 2020-10
• Subjects: coronavirus infections -- SARS-CoV-2 -- COVID-19 -- newborn -- acute respiratory distress syndrome; Communicable diseases in children -- Periodicals; Infection in children -- Periodicals; 618.929
• DOI: 10.1097/INF.0000000000002862
• Languages: English
• ISSNs: 0891-3668

Abstract

Abstract : Background: Coronavirus disease 2019 (COVID-19) primarily affects adults and spares children, whereas very little is known about neonates. We tried to define the clinical characteristics, risk factors, laboratory, and imagining results of neonates with community-acquired COVID-19. Methods: This prospective multicentered cohort study included 24 neonatal intensive care units around Turkey, wherein outpatient neonates with COVID-19 were registered in an online national database. Full-term and premature neonates diagnosed with COVID-19 were included in the study, whether hospitalized or followed up as ambulatory patients. Neonates without severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) via reverse transcriptase-polymerase chain reaction testing or whose mothers had been diagnosed with COVID-19 during pregnancy were excluded. Results: Thirty-seven symptomatic neonates were included. The most frequent findings were fever, hypoxemia, and cough (49%, 41%, 27%, respectively). Oxygen administration (41%) and noninvasive ventilation (16%) were frequently required; however, mechanical ventilation (3%) was rarely needed. Median hospitalization was 11 days (1–35 days). One patient with Down syndrome and congenital cardiovascular disorders died in the study period. C-reactive protein (CRP) and prothrombin time (PT) levels were found to be higher in patients who needed supplemental oxygen (0.9 [0.1–8.6] vs. 5.8 [0.3–69.2] p = 0.002, 11.9 [10.1–17.2] vs. 15.2 [11.7–18.0] p = 0.01, respectively) or who were severe/critical (1.0 [0.01–8.6] vs. 4.5 [0.1–69.2] p = 0.01, 11.7 [10.1–13.9] vs. 15.0 [11.7–18.0] p = 0.001, respectively). Conclusions: Symptomatic neonates with COVID-19 had high rates of respiratory support requirements. High CRP levels or a greater PT should alert the physician to more severe disease.