Characteristics and Frequency of Pediatric Inflammatory Bowel Disease-Associated Pancreatitis: A Japanese Nationwide Survey. Issue 1 (24th February 2022)

• Record Type: Journal Article
• Authors: Hosoi, Kenji; Minowa, Kei; Suzuki, Mitsuyoshi; Kudo, Takahiro; Ohtsuka, Yoshikazu; Tomomasa, Takeshi; Tajiri, Hitoshi; Ishige, Takashi; Yamada, Hiroyuki; Arai, Katsuhiro; Yoden, Atsushi; Ushijima, Kosuke; Aomatsu, Tomoki; Nagata, Satoru; Uchida, Keiichi; Takeuchi, Kazuo; Shimizu, Toshiaki
• Is Part Of: JPGN reports. Volume 3:Issue 1(2022)
• Page Start: e162
• Publication Date: 2022-02-24
• Subjects: Crohn disease -- ulcerative colitis -- extraintestinal manifestations -- autoimmune pancreatitis; Pediatric gastroenterology -- Periodicals; Children -- Nutrition -- Periodicals; Children -- Nutrition; Pediatric gastroenterology; Infant Nutritional Physiological Phenomena; Child Nutritional Physiological Phenomena; Gastrointestinal Diseases; Infant; Child; Periodicals; Periodical; Case Reports; 618.9233
• DOI: 10.1097/PG9.0000000000000162
• Languages: English
• ISSNs: 2691-171X

Abstract

Abstract : Objective: Acute pancreatitis (AP) develops in approximately 2% of patients with the diagnosis of inflammatory bowel disease (IBD), but the characteristics and frequency of childhood-onset IBD-associated AP in Japan have not been studied. The present study aimed to clarify the characteristics of IBD-associated AP in Japan. Methods: A nationwide survey of pediatric patients with IBD (age, <17 years) was conducted from December 2012 to March 2013 at 683 hospitals and medical centers in Japan. A secondary survey was also sent to the centers with the target patients to evaluate their characteristics. Results: The response rate to the first part of the survey was 61.2% (n = 418). In total, 871 patients with Crohn disease and 1671 patients with ulcerative colitis were enrolled. The second part of the survey found that 11 (1.3%) patients with Crohn disease and 23 (1.4%) patients with ulcerative colitis experienced IBD-associated AP caused by medication (n = 18, 53%), a primary disease (n = 11, 32%), autoimmune pancreatitis (n = 1, 3%), or an anatomical abnormality (n = 1, 3%). All the patients had only mild AP. Conclusions: IBD-associated AP was not very frequent and was generally mild. The major cause of the pancreatitis was the medication used to treat the IBD.