Absorbed-dose-to-water measurement using alanine in ultra-high-pulse-dose-rate electron beams. (21st October 2022)

• Record Type: Journal Article
• Authors: Bourgouin, Alexandra; Hackel, Thomas; Marinelli, Marco; Kranzer, Rafael; Schüller, Andreas; Kapsch, Ralf-Peter
• Is Part Of: Physics in medicine & biology. Volume 67:Number 20(2022)
• Publication Date: 2022-10-21
• Subjects: alanine dosimetry -- UHPDR -- Monte Carlo -- electron beam -- integrating current transformer (ICT); Biophysics -- Periodicals; Medical physics -- Periodicals; 610.153
• DOI: 10.1088/1361-6560/ac950b
• Languages: English
• ISSNs: 0031-9155

Abstract

Abstract: Objective . The aim of the presented study is to evaluate the dose response of the PTB's secondary standard system, which is based on alanine and electron spin resonance (ESR) spectroscopy measurement, in ultra-high-pulse-dose-rate (UHPDR) electron beams. Approach . The alanine dosimeter system was evaluated in the PTB's UHPDR electron beams (20 MeV) in a range of 0.15–6.2 Gy per pulse. The relationship between the obtained absorbed dose to water per pulse and the in-beamline charge measurement of the electron pulses acquired using an integrating current transformer (ICT) was evaluated. Monte Carlo simulations were used to determine the beam quality conversion and correction factors required to perform alanine dosimetry. Main results . The beam quality conversion factor from the reference quality 60 Co to 20 MeV obtained by Monte Carlo simulation, 1.010(1), was found to be within the standard uncertainty of the consensus value, 1.014(5). The dose-to-water relative standard uncertainty was determined to be 0.68% in PTB's UHPDR electron beams. Significance . In this investigation, the dose-response of the PTB's alanine dosimeter system was evaluated in a range of dose per pulse between 0.15 Gy and 6.2 Gy and no evidence of dose-response dependency of the PTB's secondary standard system based on alanine was observed. The alanine/ESR system was shown to be a precise dosimetry system for evaluating absorbed dose to water in UHPDR electron beams.