Histopathological Characteristics of Cutaneous Melanoma in Isfahan, Iran, from 2013 to 2018. (19th September 2022)

• Record Type: Journal Article
• Authors: Malakoutikhah, Zahra; Mohaghegh, Fatemeh; Karimi, Siavash; Rajabi, Parvin; Tabatabaei, Elham T.
• Other Names: Ahmad Nihal Academic Editor.
• Is Part Of: Journal of skin cancer. Volume 2022(2022)
• Publication Date: 2022-09-19
• Subjects: Skin -- Cancer -- Periodicals; Skin -- Cancer -- Diagnosis -- Periodicals; Skin -- Cancer -- Prevention -- Periodicals; Skin -- Cancer -- Treatment -- Periodicals; 616.99477005
• DOI: 10.1155/2022/4490648
• Languages: English
• ISSNs: 2090-2905

Abstract

Abstract : Objectives . To investigate the histopathological characteristics of cutaneous melanoma in Isfahan from 2013 to 2018, according to histopathological subtype, lesions location, Clark level, and Breslow thickness. Methods . A descriptive, retrospective study in reports of Alzahra Hospital and Dr. Rajabi Pathology Laboratory in Isfahan. Results . In total, 45 patients were included in this study. The most prevalent histopathological subtype was acral lentiginous melanoma (48.89%), followed by lentigo maligna melanoma (17.78%), nodular melanoma (11.11%), and superficial spreading melanoma (8.89%). Most malignant lesions were on the foot and toes (31.1%) and face (24.4%). Tumor invasion level was mainly at Clark level IV (42.2%). Furthermore, the mean depth of tumor penetration (Breslow thickness) was 3.87 ± 3.35. Conclusions . Our study revealed the characteristics of melanoma in the Iranian population. Our results showed a similar trend with previous studies in the Asian population. Further investigations are needed to elucidate the role of ethnic and environmental risk factors for developing melanoma in different populations.