Cu2O-Catalyzed Ullmann-type CN cross-coupling reaction of carbazole and aryl chlorides. (26th October 2022)

• Record Type: Journal Article
• Authors: Zhu, Baiyao; Xiong, Wenfang; Tan, Xiaobin; Wu, Wanqing; Jiang, Huanfeng
• Is Part Of: Tetrahedron letters. Volume 109(2022)
• Publication Date: 2022-10-26
• Subjects: Ullmann reaction -- CN cross-coupling reaction -- Chlorobenzene activation -- Carbazole derivatives; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2022.154140
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: A copper-catalyzed Ullmann-type CN cross-coupling reaction of carbazole with aryl chlorides has been developed employing N, N′ -bis(thiophene-2-ylmethyl)oxalamide as ligand. The reaction proceeds at 140 °C with Cs2 CO3 as the base in DMSO/MeCN to afford N -arylcarbazole in good to excellent yields. Both the heteroaromatic ring and amide structures in ligands are important for their efficiency.