Patterns of recurrences in sinonasal cancers undergoing an endoscopic surgery-based treatment: Results of the MUSES* on 940 patients: *MUlti-institutional collaborative Study on Endoscopically treated Sinonasal cancers. (November 2022)

• Record Type: Journal Article
• Authors: Arosio, Alberto Daniele; Bernasconi, Davide Paolo; Valsecchi, Maria Grazia; Pacifico, Claudia; Battaglia, Paolo; Bignami, Maurizio; Ferrari, Marco; Mattavelli, Davide; Rampinelli, Vittorio; Tomasoni, Michele; Schreiber, Alberto; Gualtieri, Tommaso; Piazza, Cesare; Magrini, Stefano Maria; Tartaro, Tiziana; Molteni, Marinella; Lambertoni, Alessia; Sileo, Giorgio; Bossi, Paolo; Orlandi, Ester; Bertazzoni, Giacomo; Fiaux-Camous, Domitille; Jourdaine, Clement; Verillaud, Benjamin; Herman, Philippe; Nicolai, Piero; Castelnuovo, Paolo; Turri-Zanoni, Mario
• Is Part Of: Oral oncology. Volume 134(2022)
• Publication Date: 2022-11
• Subjects: Paranasal sinus cancer -- Metastasis -- Endoscopic surgery, recurrence -- Follow-up studies -- Survivors -- Prognosis -- Sinonasal intestinal-type adenocarcinoma -- Olfactory neuroblastoma -- Mucosal melanoma; AAR age at recurrence -- AC adenoid-cystic carcinoma -- AWD alive with disease -- CER cranioendoscopic resection -- ChT chemotherapy -- CI confidence interval -- DFS disease free survival -- D-RFS distant recurrence free survival -- DOC dead of other cause -- DOD dead of disease -- DSS disease specific survival -- ER endoscopic resection -- ERTC endoscopic resection with transnasal craniectomy -- HR hazard ratio -- iCHT induction chemotherapy -- LGMSFT low grade malignant soft tissue tumors -- MM mucosal melanomas MUSES -- L-RFS local recurrence free survival MUlti-institutional collaborative Study on Endoscopically treated Sinonasal cancers -- NED no evidence of disease -- NOS not otherwise specified -- ONB olfactory neuroblastoma -- OS overall survival -- PNI perineural invasion -- RFS recurrence-free survival -- R-RFS regional recurrence free survival -- SAR survival after recurrence -- SGC salivary gland cancer -- SNAC sinonasal adenocarcinomas -- SNCs sinonasal cancers -- SNSCC sinonasal squamous cell carcinoma -- SNEC sinonasal neuroendocrine carcinoma -- SNUC sinonasal undifferentiated carcinoma -- SOR site of recurrence -- STT soft tissue tumors -- TTR time to recurrence; Mouth -- Cancer -- Periodicals; Mouth -- Tumors -- Periodicals; Mouth Diseases -- Periodicals; Mouth Neoplasms -- Periodicals; Bouche -- Cancer -- Périodiques; Bouche -- Tumeurs -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9943105
• DOI: 10.1016/j.oraloncology.2022.106123
• Languages: English
• ISSNs: 1368-8375

Abstract

Highlights: Oncologic results in a cohort of sinonasal cancers treated with endoscopic surgery. Global recurrence rate of 32.9%, predominantly local and distant failures. Failure significantly impacts on survival, with low survival after recurrence rates. Patterns of recurrence are significantly different across histology types. Multidisciplinary approach and intensive follow-up are crucial to improve outcomes. Abstract: Objectives: The improvements in survival with expansion of the survivors' population, along with evolution of endoscopically-based treatment modalities, have contributed to emphasize the clinical relevance of recurrences in sinonasal cancers. However, at present, literature is scant regarding the pattern of recurrences and the therapeutic strategies available to manage long survivors who experienced single or multiple failures. The aim of the present study was to analyze sinonasal cancers recurrences to provide data regarding rates and patterns of relapse, predictors of failure and prognostic impact of the recurrence. Materials and Methods: All patients receiving multimodal treatments including endoscopic surgery between 1995 and 2021 in three European referral centers were included. Statistical analysis of survival was performed through univariable, multivariable and unidirectional multistate models. Survival after recurrence analysis was implemented for patients experiencing at least one recurrence. Results: The 5- and 10-year recurrence free survival rates were 34.1% and 38.4% for the whole population. With a mean follow-up time of 60 months, a global recurrence rate of 32.9% was observed. The 5- and 10-year survival after recurrence rates were 27.2% and 21.7%, respectively. Incidence and rates of recurrences were significantly associated with histology subtypes. Conclusion: This study provides valuable oncologic outcomes regarding a large homogenous cohort of patients affected by sinonasal malignances treated within a multimodal framework, emphasizing the strong correlation of histologic type with prognosis, as well as with pattern of recurrences.