East Coast fever, a neglected tropical disease with an outdated vaccine approach?. Issue 11 (November 2022)

• Record Type: Journal Article
• Authors: Kolakowski, Jeannine; Connelley, Tim; Lukacik, Petra; Pfuhl, Mark; Werling, Dirk
• Is Part Of: Trends in parasitology. Volume 38:Issue 11(2022)
• Page Start: 930
• Page End: 932
• Publication Date: 2022-11
• Subjects: Theileria parva -- drug resistance -- infection and treatment method (ITM) -- glycobiology -- protein modelling -- cellular immunity; Parasitology -- Periodicals; Parasitology -- Periodicals; Biology -- Periodicals; Parasitology; Biology; Parasitologie -- Périodiques; Online resources; 571.999
• DOI: 10.1016/j.pt.2022.08.006
• Languages: English
• ISSNs: 1471-4922

Abstract

Abstract : Since its discovery, bovine theileriosis has caused major socioeconomic losses in sub-Saharan Africa. Acaricide resistance of the intermediate host, paucity of therapeutics, and lack of sufficiently cross-protective vaccines increase the risk of parasite spread due to global warming. Here, we highlight three important areas that require investigation to develop next-generation vaccines.