The interconnections between the microtubules and mitochondrial networks in cardiocerebrovascular diseases: Implications for therapy. (October 2022)

• Record Type: Journal Article
• Authors: Shi, Xingjuan; Jiang, Xuan; Chen, Congwei; Zhang, Yu; Sun, Xiaoou
• Is Part Of: Pharmacological research. Volume 184(2022)
• Publication Date: 2022-10
• Subjects: MAP microtubule-associated protein -- PTM post-translational modification -- HDAC6 Histone Deacetylase 6 -- Drp1 Dynamin-related protein 1 -- Miro Mitochondrial Rho-GTPase, TRAK, Trafficking kinesin-binding protein -- MNTs membrane nanotubes -- KIF5B kinesin family member 5B -- ACE angiotensin-converting enzyme -- ARB angiotensin receptor blocker -- DCM dilated cardiomyopathy -- LVEF left ventricular ejection fraction -- HF heart failure -- BNP natriuretic peptide B -- CHF congestive heart failure -- MI Myocardial infarction -- hsTnT high-sensitivity troponin T -- CK-MB creatine kinase-myocardial brain fraction -- AMI acute myocardial infarction -- Tubb2a tubulin beta 2a -- TPPP/ p25 Tubulin polymerization promoting protein -- VASH2 vasohibin 2 -- IL interleukin -- NLRP3 NOD-like receptor protein 3 -- MARK4 microtubule-affinity regulating kinase 4 -- hs-CRP high-sensitivity C-reactive protein -- LDL low-density lipoprotein -- HUVEC human umbilical vein endothelial cells -- oxLDL oxidized LDL -- MCAO middle cerebral artery occlusion -- TubA Tubastatin A -- FGF-21 fibroblast growth factor-21 -- IGF-1 insulin-like growth factor 1 -- ICH intracerebral hemorrhage -- aSAH aneurysmal subarachnoid haemorrhage -- mPTP mitochondrial permeability transition pore -- Cx43 Connexin 43 -- IR ischemia-reperfusion -- Mdivi-1 mitochondrial division inhibitor 1; Microtubules -- Mitochondria -- Cardiocerebrovascular diseases; Pharmacology -- Periodicals; Pharmacology -- Periodicals; Research -- Periodicals; Médicaments -- Recherche -- Périodiques; Pharmacologie -- Périodiques; 615.105
• DOI: 10.1016/j.phrs.2022.106452
• Languages: English
• ISSNs: 1043-6618

Abstract

Abstract: Microtubules, a highly dynamic cytoskeleton, participate in many cellular activities including mechanical support, organelles interactions, and intracellular trafficking. Microtubule organization can be regulated by modification of tubulin subunits, microtubule-associated proteins (MAPs) or agents modulating microtubule assembly. Increasing studies demonstrate that microtubule disorganization correlates with various cardiocerebrovascular diseases including heart failure and ischemic stroke. Microtubules also mediate intracellular transport as well as intercellular transfer of mitochondria, a power house in cells which produce ATP for various physiological activities such as cardiac mechanical function. It is known to all that both microtubules and mitochondria participate in the progression of cancer and Parkinson's disease. However, the interconnections between the microtubules and mitochondrial networks in cardiocerebrovascular diseases remain unclear. In this paper, we will focus on the roles of microtubules in cardiocerebrovascular diseases, and discuss the interplay of mitochondria and microtubules in disease development and treatment. Elucidation of these issues might provide significant diagnostic value as well as potential targets for cardiocerebrovascular diseases. Graphical Abstract: ga1