A renewed concept on the MAPK signaling pathway in cancers: Polyphenols as a choice of therapeutics. (October 2022)

• Record Type: Journal Article
• Authors: Anjum, Juhaer; Mitra, Saikat; Das, Rajib; Alam, Roksana; Mojumder, Anik; Emran, Talha Bin; Islam, Fahadul; Rauf, Abdur; Hossain, Md. Jamal; Aljohani, Abdullah S.M.; Abdulmonem, Waleed Al; Alsharif, Khalaf F.; Alzahrani, Khalid J.; Khan, Haroon
• Is Part Of: Pharmacological research. Volume 184(2022)
• Publication Date: 2022-10
• Subjects: WHO world health organization -- MAPK mitogen-activated protein kinase -- ERK extracellular signal-regulated kinase -- JNK c-Jun NH2- terminal kinase -- NF-κB factor-kappa B -- Nrf2 nuclear factor E2-related factor 2 -- MMP matrix metalloproteinases -- COX-2 cyclooxygenase -- MEK mitogen-activated extracellular signal-regulated kinase -- BRAF serine/threonine-protein kinase B-raf -- AP1 activator protein 1 -- ANS anthocyanin synthase -- DMBA 7, 12–dimethylbenzanthracene -- ROS reactive oxygen species -- DCF dichlorodihydrofluorescein -- FRAP ferric ion reducing antioxidant power -- MMP-9 matrix metalloproteinase-9 -- AhR aryl hydrocarbon receptor -- NNK nicotine-derived nitrosamine ketone -- NK natural killer -- PCNSA proliferating cell nuclear antigen -- TIMP-2 tissue inhibitor of metalloproteinase-2 -- PARP poly (ADP-ribose) polymerase -- AMPK AMP-activated protein kinase -- BMP 9 bone morphogenetic protein 9 -- BMP 7 bone morphogenetic protein 7 -- HIF-1 hypoxia-inducible factor 1 -- PI3K phosphoinositide-3-kinase -- PKC protein kinase C -- TNF-α tumor necrosis factor alpha; Polyphenols -- MAPK signaling pathway -- Cancer -- Apoptosis -- ERK -- P38 -- JNK; Pharmacology -- Periodicals; Pharmacology -- Periodicals; Research -- Periodicals; Médicaments -- Recherche -- Périodiques; Pharmacologie -- Périodiques; 615.105
• DOI: 10.1016/j.phrs.2022.106398
• Languages: English
• ISSNs: 1043-6618

Abstract

Abstract: Abnormalities in the mitogen-activated protein kinase (MAPK) signaling pathway are a key contributor to the carcinogenesis process and have therefore been implicated in several aspects of tumorigenesis, including cell differentiation, proliferation, invasion, angiogenesis, apoptosis, and metastasis. This pathway offers multiple molecular targets that may be modulated for anticancer activity and is of great interest for several malignancies. Polyphenols from various dietary sources have been observed to interfere with certain aspects of this pathway and consequently play a substantial role in the development and progression of cancer by suppressing cell growth, inactivating carcinogens, blocking angiogenesis, causing cell death, and changing immunity. A good number of polyphenolic compounds have shown promising outcomes in numerous pieces of research and are currently being investigated clinically to treat cancer patients. The current study concentrates on the role of the MAPK pathway in the development and metastasis of cancer, with particular emphasis on dietary polyphenolic compounds that influence the different MAPK sub-pathways to obtain an anticancer effect. This study aims to convey an overview of the various aspects of the MAPK pathway in cancer development and invasion, as well as a review of the advances achieved in the development of polyphenols to modulate the MAPK signaling pathway for better treatment of cancer. Graphical Abstract: ga1