Association between COVID-19 infection and work exposure assessed by the Mat-O-Covid job exposure matrix in the CONSTANCES cohort. Issue 11 (20th September 2022)

• Record Type: Journal Article
• Authors: Fadel, Marc; Gilbert, Fabien; Legeay, Clément; Dubée, Vincent; Esquirol, Yolande; Verdun-Esquer, Catherine; Dinh, Aurelien; Sembajwe, Grace; Goldberg, Marcel; Roquelaure, Yves; Leclerc, Annette; Wiernik, Emmanuel; Zins, Marie; Descatha, Alexis
• Other Names: author non-byline.; Descatha Alexis author non-byline.; Fadel Marc author non-byline.; Pitet Sabrina author non-byline.; Gilbert Fabien author non-byline.; Valter Rémi author non-byline.; Verdun-Esquer Catherine author non-byline.; Esquirol Yolande author non-byline.; Legeay Clément author non-byline.; Petit Audrey author non-byline.; Dinh Aurélien author non-byline.; Andujar Pascal author non-byline.; Leclerc Jean-Pierre author non-byline.; Letheux Corinne author non-byline.; Duprat Pascal author non-byline.; Clodoré Brigitte author non-byline.; Cartégnie Sandrine author non-byline.; Dagrenat Céline author non-byline.; Dab William author non-byline.; Clin-Godard Bénédicte author non-byline.; Gehanno Jean-François author non-byline.; Dubée Vincent author non-byline.; Havette Philippe author non-byline.
• Is Part Of: Occupational and environmental medicine. Volume 79:Issue 11(2022)
• Page Start: 782
• Page End: 789
• Publication Date: 2022-09-20
• Subjects: Epidemiology -- COVID-19 -- Occupational Health -- Public health; Medicine, Industrial -- Periodicals; Environmental health -- Periodicals; 616.980305
• DOI: 10.1136/oemed-2022-108436
• Languages: English
• ISSNs: 1351-0711

Abstract

Abstract : Objectives: The COVID-19 pandemic has brought to light a new occupational health threat. We aimed to evaluate the association between COVID-19 infection and work exposure to SARS-CoV-2 assessed by a job-exposure matrix (JEM), in a large population cohort. We also estimated the population-attributable fraction among exposed subjects. Methods: We used the SAPRIS-SERO sample of the CONSTANCES cohort, limited to subjects actively working, and with a job code available and a questionnaire on extra work activities. The following outcomes were assessed: COVID-19 diagnosis was made by a physician; a seropositivity to the ELISA-S test ('serology strict') and ELISA-S test intermediate with positive ELISA-NP or a positive neutralising antibodies SN ('serology large'). Job exposure was assessed using Mat-O-Covid, an expert-based JEM with an Index used as a continuous variable and a threshold at 13/1000. Results: The sample included 18 999 subjects with 389 different jobs, 47.7% were men with a mean age of 46.2 years (±9.2 years). The Mat-O-Covid index taken as a continuous variable or with a threshold greater than 13/1000 was associated with all the outcomes in bivariable and multivariable logistic models. ORs were between 1.30 and 1.58, and proportion of COVID-19 attributable to work among exposed participants was between 20% and 40%. Discussion: Using the Mat-O-Covid JEM applied to a large population, we found a significant association between work exposure to SARS-CoV-2 and COVID-19 infection, though the estimation of attributable fraction among exposed people remained low to moderate. Further studies during other exposed periods and with other methods are necessary.