Dose optimisation and scarce resource allocation: two sides of the same coin. Issue 10 (12th October 2022)

• Record Type: Journal Article
• Authors: Strohbehn, Garth; Persad, Govind; Parker, William F; Murthy, Srinivas
• Is Part Of: BMJ open. Volume 12:Issue 10(2022)
• Publication Date: 2022-10-12
• Subjects: CLINICAL PHARMACOLOGY -- Clinical trials -- MEDICAL ETHICS -- COVID-19 -- Public health -- Rationing; Medicine -- Research -- Periodicals; 610.72
• DOI: 10.1136/bmjopen-2022-063436
• Languages: English
• ISSNs: 2044-6055

Abstract

Abstract : Objective: A deep understanding of the relationship between a scarce drug's dose and clinical response is necessary to appropriately distribute a supply-constrained drug along these lines. Summary of key data: The vast majority of drug development and repurposing during the COVID-19 pandemic – an event that has made clear the ever-present scarcity in healthcare systems –has been ignorant of scarcity and dose optimisation's ability to help address it. Conclusions: Future pandemic clinical trials systems should obtain dose optimisation data, as these appear necessary to enable appropriate scarce resource allocation according to societal values.