Issue Information. Issue 9 (28th September 2022)

• Record Type: Journal Article
• Is Part Of: Current protocols. Volume 2:Issue 9(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-09-28
• Subjects: Life sciences -- Laboratory manuals -- Periodicals; Biology -- Laboratory manuals -- Periodicals; Life sciences -- Technique -- Periodicals; Biology -- Technique -- Periodicals; 570.028
• DOI: 10.1002/cpz1.168
• Languages: English
• ISSNs: 2691-1299

Abstract

Abstract : Cover : Tumor spheroids are widely used for drug screening as in vitro models of the tumor microenvironment. There are various ways in which these 3D models can be prepared, and in recent years, drug high‐throughput screening (HTS) approaches have incorporated the use of these culture systems. These HTS platforms, however, typically require complicated equipment such as robot arms, detectors, and software for handling solutions and data processing. Microfluidic devices can also be used as a platform to test drug efficacy in a high‐throughput manner. In this issue, Lee et al . describe protocols for generating tumor spheroids and testing them with different concentrations of a drug in a parallel fashion using a microfluidic device that generates a gradient of the drug of interest. The cover image depicts how different concentrations of drugs can be generated within the microfluidic device and delivered to tumor spheroids. Image provided by the authors and created with BioRender.com .