Contribution of the "Click Chemistry" Toolbox for the Design, Synthesis, and Resulting Applications of Innovative and Efficient Separative Supports: Time for Assessment. Issue 19 (26th June 2022)

• Record Type: Journal Article
• Authors: Le Droumaguet, Benjamin; Guerrouache, Mohamed; Carbonnier, Benjamin
• Is Part Of: Macromolecular rapid communications. Volume 43:Issue 19(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-06-26
• Subjects: chromatography -- click chemistry -- selectors -- separation sciences -- stationary phase -- surface functionalization; Macromolecules -- Periodicals; Polymers -- Periodicals; Chemistry -- Periodicals; 547.705
• DOI: 10.1002/marc.202200210
• Languages: English
• ISSNs: 1022-1336

Abstract

Abstract: The last two decades have seen the rapid expansion of click chemistry methodology in various domains closely related to organic chemistry. It has notably been widely developed in the area of surface chemistry, mainly because of the high‐yielding character of reactions of the "click" type. Especially, this powerful chemical reaction toolbox has been adapted to the preparation of stationary phases from the corresponding chromatographic supports. A plethora of selectors can thus be immobilized on either organic, inorganic, or hybrid stationary phases that can be used in different chromatographic modes. This review first highlights the few different chemical ligation strategies of the "click" type that are up to now mainly devoted to the development of functionalized supports for separation sciences. Then, it gives in a second part an up‐to‐date survey of the different studies dedicated to the preparation of click chemistry‐based chromatographic supports while highlighting the powerful and versatile character of the "click" ligation strategy for the design, synthesis, and developments of more and more complex systems that can find promising applications in the area of analytical sciences, in domains as varied as enantioselective separation, glycomics, proteomics, genomics, metabolomics, etc. Abstract : This review highlights the contribution of "click" chemistry reactions (copper‐catalyzed azide–alkyne cycloaddition, thiol–ene/yne radical addition) to the design of stationary phases for applications in the rapidly expanding field of analytical sciences. It notably gives an exhaustive landscape of the great number of selectors that can be anchored to chromatographic supports and to their resulting implementation for analyte separation.