Preparation of nano‐micelles of meloxicam for transdermal drug delivery and simulation of drug release: A computational supported experimental study. (1st March 2022)

• Record Type: Journal Article
• Authors: Poustforoosh, Alireza; Hashemipour, Hassan; Pardakhty, Abbas; Pour, Maryam Kalantari
• Is Part Of: Canadian journal of chemical engineering. Volume 100:Number 11(2022)
• Page Start: 3428
• Page End: 3436
• Publication Date: 2022-03-01
• Subjects: drug delivery -- meloxicam -- microemulsion -- simulation -- surfactant; Chemical engineering -- Periodicals; Technology -- Periodicals; 660.05
• DOI: 10.1002/cjce.24339
• Languages: English
• ISSNs: 0008-4034

Abstract

Abstract: Meloxicam (MLX) is a generic drug with a wide range of pharmaceutical applications in the world. In this study, the nanostructural form of MLX was prepared using the microemulsion (ME) method. The size distribution of droplets was measured by dynamic light scattering (DLS). Among several substances, oleic acid was chosen as the oily phase, and Tween 80/PEG 400 (1/1) and Tween 80/ethanol (2/1) were selected as surfactants and co‐surfactants to create a stable and large area of the ME zone. The droplet sizes for MEs created for Tween/ethanol and Tween/PEG 400 were about 13 and 800 nm, respectively. This shows that the ME is in the form of nano‐micelles. Despite the small size of Tween/ethanol, the release amount of the drug from Tween/PEG 400 was higher. The release rate of the drug formulation and its variation were experimentally investigated in the Franz diffusion cell using UV spectroscopy detection. In addition, the simulation of the drug release was carried out. The diffusion coefficient of Tween 80/ethanol (1/1), calculated using the simulation, was about 16.8 × 10 −13 cm 2 /s, and it was predicted that the maximum percentage of release after 24 h would be about 70%. Finally, the release of MLX in the skin tissue was predicted by applying the rate of metabolism in the simulation. The results showed that the maximum percentage of MLX released into the skin was about 40%.