Mobilizing the clinical trial ecosystem to drive adoption of master protocols. (December 2022)

• Record Type: Journal Article
• Authors: Bronson, Abby; Chase, Marianne K; Fisher, Kimberly; Millar, Daniel; Perlmutter, Jane; Richardson, Nicholas
• Is Part Of: Clinical trials. Volume 19:Number 6(2022)
• Page Start: 690
• Page End: 696
• Publication Date: 2022-12
• Subjects: Master protocol studies -- clinical trial design -- basket trials -- umbrella trials -- multiple targeted therapies -- platform trials -- patient-centric clinical trial design -- clinical research funding -- collaboration; 615.5072405
• DOI: 10.1177/17407745221110199
• Languages: English
• ISSNs: 1740-7745

Abstract

Master protocol studies typically use an overarching protocol to answer several questions by guiding a variety of sub-studies. These sub-studies can incorporate multiple diseases, therapies, or both. Although this innovative approach offers many benefits, including the ability to deliver clinical research that is more patient-centric and efficient, several common barriers curtail widespread adoption. The Clinical Trials Transformation Initiative (CTTI) convened industry representatives, regulatory agencies, patient groups, and academic institutions to identify emerging best practices and develop resources designed to help sponsors and other stakeholders overcome these challenges. We first identify some broad changes needed in the clinical trials ecosystem to facilitate mainstream adoption of master protocol studies, and we subsequently summarize CTTI's resources designed to support this effort.