Long‐term outcome of cerebral amyloid angiopathy‐related hemorrhage. (16th August 2022)

• Record Type: Journal Article
• Authors: Che, Ruiwen; Zhang, Mengke; Sun, Hailiang; Ma, Jin; Hu, Wenbo; Liu, Xin; Ji, Xunming
• Is Part Of: CNS neuroscience & therapeutics. Volume 28:Number 11(2022)
• Page Start: 1829
• Page End: 1837
• Publication Date: 2022-08-16
• Subjects: cerebral amyloid angiopathy -- cerebral small vessel diseases -- intracranial hemorrhages -- neuroimaging -- survival analysis -- treatment outcome; Neuropharmacology -- Periodicals; Central nervous system -- Diseases -- Effect of drugs on -- Periodicals; 612.8
• DOI: 10.1111/cns.13922
• Languages: English
• ISSNs: 1755-5930

Abstract

Abstract: Object: The long‐term functional outcome of cerebral amyloid angiopathy‐related hemorrhage (CAAH) patients is unclear. We sought to assess the long‐term functional outcome of CAAH and determine the prognostic factors associated with unfavorable outcomes. Methods: We enrolled consecutive CAAH patients from 2014 to 2020 in this observational study. Baseline characteristics and clinical outcomes were presented. Multivariable logistic regression analysis was performed to identify the prognostic factors associated with long‐term outcome. Results: Among the 141 CAAH patients, 76 (53.9%) achieved favorable outcomes and 28 (19.9%) of them died at 1‐year follow‐up. For the longer‐term follow‐up with a median observation time of 19.0 (interquartile range, 12.0–26.5) months, 71 (50.4%) patients obtained favorable outcomes while 33 (23.4%) died. GCS on admission (OR, 0.109; 95% CI, 0.021–0.556; p = 0.008), recurrence of ICH (OR, 2923.687; 95% CI, 6.282–1360730.14; p = 0.011), WML grade 3–4 (OR, 31.007; 95% CI, 1.041–923.573; p = 0.047), severe central atrophy (OR, 4220.303; 95% CI, 9.135–1949674.84; p = 0.008) assessed by CT was identified as independent predictors for long‐term outcome. Interpretation: Nearly 50% of CAAH patients achieved favorable outcomes at long‐term follow‐up. GCS, recurrence of ICH, WML grade and cerebral atrophy were identified as independent prognostic factors of long‐term outcome. Abstract : The long‐term functional outcome of cerebral amyloid angiopathy‐related hemorrhage (CAAH) patients is unclear. In our study, we enrolled consecutive CAAH patients from 2014 to 2020. Among the 141 CAAH patients, 76 (53.9%) achieved favorable outcomes and 19.9% of them died at 1‐year follow‐up. For the longer‐term follow‐up with a median observation time of 19.0 (interquartile range, 12.0–26.5) months, 71 (50.4%) patients obtained favorable outcomes and 33 (23.4%) of them died. Multivariable logistic regression analysis was performed to identify the prognostic factors associated with long‐term outcome. GCS, recurrence of ICH, WML grade 3‐4 and severe cerebral atrophy were identified as independent prognostic factors of long‐term outcome.