Comparison of 24‐hour urinary creatinine clearance and estimated glomerular filtration rate based on a panel of filtration markers in patients with chronic kidney disease. Issue 5 (7th September 2022)

• Record Type: Journal Article
• Authors: Iversen, Esben; Boesby, Lene; Hansen, Ditte; Houlind, Morten Baltzer
• Is Part Of: Pharmacology research & perspectives. Volume 10:Issue 5(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-09-07
• Subjects: beta‐2 microglobulin -- beta‐trace protein -- chronic kidney disease -- creatinine -- cystatin C -- estimated glomerular filtration rate -- panel equation; Pharmacology -- Periodicals; Drug development -- Periodicals; 615.105
• DOI: 10.1002/prp2.1002
• Languages: English
• ISSNs: 2052-1707

Abstract

Abstract: Diagnosis and management of chronic kidney disease (CKD) requires accurate assessment of glomerular filtration rate (GFR). In practice, GFR is typically estimated by equations based on creatinine concentration in blood, but creatinine is affected by non‐GFR factors such as age and sex. Alternative filtration markers such as cystatin C, beta‐trace protein (BTP), and beta‐2 microglobulin (B2M) may be less dependent on age and sex, but equations combining these markers have not been investigated in patients with chronic kidney disease (CKD). In this cross‐sectional study of 50 patients with CKD stage 3–4, we compared kidney function estimates based on creatinine, cystatin C, BTP, B2M, or a combination of markers. Compared to the creatinine/cystatin C combination equation, the panel equation yielded a mean difference of only 2.8 ml/min/1.73 m 2, indicating that switching to the panel equation would be unlikely to affect management.