Gastrointestinal symptoms and endoscopy findings after pediatric solid organ transplantation: A case series. (11th August 2022)

• Record Type: Journal Article
• Authors: Ylinen, Elisa; Merras‐Salmio, Laura; Jahnukainen, Timo
• Is Part Of: Pediatric transplantation. Volume 26:Number 7(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-08-11
• Subjects: children -- de novo inflammatory bowel disease -- diarrhea -- ileocolonoscopy -- post‐transplant lymphoproliferative disorder -- transplantation; Transplantation of organs, tissues, etc. in children -- Periodicals; 617.95408305
• DOI: 10.1111/petr.14374
• Languages: English
• ISSNs: 1397-3142

Abstract

Abstract: Background: Gastrointestinal symptoms are common among solid organ transplant (SOT) recipients. Information about colonoscopy findings after pediatric SOT is limited. This retrospective study reports endoscopy findings in a nationwide pediatric transplant recipient cohort. Methods: All pediatric recipients (kidney, liver, or heart) transplanted between 2010 and 2020 at our institution ( n = 193) who had undergone ileocolonoscopy and upper gastrointestinal endoscopy after SOT were enrolled. Sixteen patients were identified. A meticulous search on clinical data including transplantation, gastrointestinal symptoms, endoscopy findings, and follow‐up data was performed. Results: Endoscopy was performed at a median of 2.6 years (0.4–13.3) after the first transplantation (median age at SOT 1.2 years). Gastrointestinal symptoms leading to endoscopy did not differ between the different transplant groups. The leading endoscopy indications were prolonged diarrhea and anemia. PTLD was found in 8 (50%) patients. Five were histologically early PTLD lesions and three were monomorphic large B‐cell PTLDs (two EBV‐positive and one EBV‐negative), one having previously been diagnosed with autoimmune enteropathy. One patient had EBV enteritis. De novo inflammatory bowel disease was found in one patient, eosinophilic gastroenteritis in another, and in one patient with several episodes of watery diarrhea, the histological finding was mild non‐specific colitis. In four patients, the endoscopy finding remained unclear and the symptoms were suspected to be caused by infectious agents or mycophenolate. Conclusions: PTDL with various stages is a common finding after pediatric SOT in patients with gastrointestinal symptoms. Endoscopy should be considered in transplant recipients with prolonged diarrhea, anemia, and/or abdominal pain.