Posttreatment FDG‐PET/CT Hopkins criteria predict locoregional recurrence after definitive radiotherapy for oropharyngeal squamous cell carcinoma. Issue 11 (3rd August 2022)

• Record Type: Journal Article
• Authors: Miller, Jacob A.; Moradi, Farshad; Sundaram, Vandana; Liang, Rachel; Zhang, Carrie; Nguyen, Ngan Kim; Akhtar, Faisal; Liu, Yuhan; Ren, Yulan; Harandi, Nima; Weng, Yingjie; Pollom, Erqi L.; Colevas, Alexander Dimitrios; Divi, Vasu; Holsinger, Floyd Christopher; Beadle, Beth M.; Le, Quynh‐Thu; Gensheimer, Michael F.
• Is Part Of: Head & neck. Volume 44:Issue 11(2022)
• Page Start: 2491
• Page End: 2504
• Publication Date: 2022-08-03
• Subjects: Hopkins criteria -- locoregional recurrence -- oropharynx cancer -- PET/CT -- response assessment; Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.27160
• Languages: English
• ISSNs: 1043-3074

Abstract

Abstract: Background: Metabolic response assessment for oropharyngeal squamous cell carcinoma (OPSCC) aids in identifying locoregional persistence/recurrence (LRR). The Hopkins Criteria are a standardized qualitative response assessment system using posttreatment FDG‐PET/CT. Methods: We conducted a retrospective cohort study of patients with node‐positive OPSCC treated with definitive (chemo)radiotherapy. We assessed Hopkins Criteria performance for LRR, then developed and validated a competing‐risks model. Results: Between 2004 and 2018, 259 patients were included with median follow‐up of 43 months. The Hopkins Criteria sensitivity, specificity, negative predictive value, and accuracy were 68%, 88%, 95%, and 85%. The 36‐month cumulative incidence of LRR was greater with positive scores (45% vs. 5%, HR 12.60, p < 0.001). PET/CTs performed ≤10 weeks after radiotherapy were associated with a four‐fold increase in pathologically negative biopsies/surgeries (36% vs. 9%, p = 0.03). The AUC for LRR was 0.89 using a model integrating the Hopkins score. Conclusions: The Hopkins Criteria predict LRR with high accuracy for OPSCC response assessment.