Guidelines of the International Headache Society for Controlled Clinical Trials in Cluster Headache. (December 2022)

• Record Type: Journal Article
• Authors: Schoenen, Jean; Snoer, Agneta Henriette; Brandt, Roemer B; Fronczek, Rolf; Wei, Diana Y; Chung, Chin-Sang; Diener, Hans-Christoph; Dodick, David W; Fontaine, Denys; Goadsby, Peter J; Matharu, Manjit Singh; May, Arne; McGinley, James S; Tepper, Stewart J; Jensen, Rigmor Højland; Ferrari, Michel D
• Other Names: Schoenen Jean non-byline-author.; Jensen Rigmor non-byline-author.; Ferrari Michel D non-byline-author.; May Arne non-byline-author.; Diener Hans-Christoph non-byline-author.; Goadsby Peter J non-byline-author.; Matharu Manjit S non-byline-author.; Tepper Stewart J non-byline-author.; Dodick David W non-byline-author.; Chung Chin-Sang non-byline-author.; Fontaine Denys non-byline-author.; McGinley James S non-byline-author.; Snoer Agneta Henriette non-byline-author.; Fronczek Rolf non-byline-author.; Brandt Roemer W non-byline-author.; Wei Diana Y non-byline-author.; Terwindt Gisela non-byline-author.; Tassorelli Cristina non-byline-author.; Diener Hans-Christoph non-byline-author.; Ashina Messoud non-byline-author.; Goadsby Peter J non-byline-author.; Leroux Elizabeth non-byline-author.; Lipton Richard B non-byline-author.; Pozo-Rosich Patricia non-byline-author.; Wang Shuu-Jiun non-byline-author.; Christensen Marie Deen non-byline-author.; Martini Daniela non-byline-author.; van den Hoek Thomas non-byline-author.
• Is Part Of: Cephalalgia. Volume 42:Number 14(2022)
• Page Start: 1450
• Page End: 1466
• Publication Date: 2022-12
• Subjects: Guidelines -- classifications -- ICHD-3 -- cluster headache; Headache -- Periodicals; 616.8491
• DOI: 10.1177/03331024221120266
• Languages: English
• ISSNs: 0333-1024

Abstract

In 1995, a committee of the International Headache Society developed and published the first edition of the Guidelines for Controlled Trials of Drugs in Cluster Headache. These have not been revised. With the emergence of new medications, neuromodulation devices and trial designs, an updated version of the International Headache Society Guidelines for Controlled Clinical Trials in Cluster Headache is warranted. Given the scarcity of evidence-based data for cluster headache therapies, the update is largely consensus-based, but takes into account lessons learned from recent trials and demands by patients. It is intended to apply to both drug and neuromodulation treatments, with specific proposals for the latter when needed. The primary objective is to propose a template for designing high quality, state-of-the-art, controlled clinical trials of acute and preventive treatments in episodic and chronic cluster headache. The recommendations should not be regarded as dogma and alternative solutions to particular methodological problems should be explored in the future and scientifically validated.