Biomarkers of endothelial dysfunction and atherosclerosis in hidradenitis suppurativa. Issue 10 (6th June 2022)

• Record Type: Journal Article
• Authors: González‐López, Marcos A.; Ocejo‐Viñals, J. Gonzalo; López‐Sundh, Ana E.; Guiral, Sandra; Ruiz‐Solana, Marta; Mata, Cristina; Portilla, Virginia; Corrales, Alfonso; Blanco, Ricardo; Hernández, Jose L.
• Is Part Of: Journal of dermatology. Volume 49:Issue 10(2022)
• Page Start: 1052
• Page End: 1056
• Publication Date: 2022-06-06
• Subjects: angiopoietin‐2 -- asymmetric dimethylarginine -- endothelial dysfunction -- hidradenitis suppurativa -- osteoprotegerin; Dermatology -- Periodicals; Dermatology -- Japan -- Periodicals; Skin -- Diseases -- Periodicals; 616.5005
• DOI: 10.1111/1346-8138.16484
• Languages: English
• ISSNs: 0385-2407

Abstract

Abstract: Hidradenitis suppurativa (HS) is a chronic inflammatory disease associated with an increased prevalence of subclinical atherosclerosis and cardiovascular risk. Angiopoietin‐2 (Ang‐2), asymmetric dimethylarginine (ADMA), and osteoprotegerin (OPG) are molecules related to endothelial dysfunction (ED) and atherosclerosis, but also to disease severity in patients with chronic inflammatory disorders. In this case–control study, we aimed to investigate serum Ang‐2, ADMA, and OPG levels in patients with HS, and to assess the potential relationship between these levels and disease severity. Seventy‐five patients with HS and 60 controls were assessed. Serum Ang‐2, ADMA, and OPG concentrations were determined in all participants. HS patients had significantly higher Ang‐2 and ADMA levels than controls after adjusting for confounders. Besides, Ang‐2 concentrations positively correlated with disease severity in the adjusted multivariable analysis. Nevertheless, serum OPG levels did not significantly differ between HS patients and controls. Our results indicate that serum Ang‐2 and ADMA levels are significantly increased in patients with HS. Furthermore, Ang‐2 might be a suitable marker of HS severity.