Front Cover: The First Class of Small Molecules Potently Disrupting the YAP‐TEAD Interaction by Direct Competition (ChemMedChem 19/2022). (6th October 2022)

• Record Type: Journal Article
• Authors: Furet, Pascal; Bordas, Vincent; Le Douget, Mickaël; Salem, Bahaa; Mesrouze, Yannick; Imbach‐Weese, Patricia; Sellner, Holger; Voegtle, Markus; Soldermann, Nicolas; Chapeau, Emilie; Wartmann, Markus; Scheufler, Clemens; Fernandez, Cesar; Kallen, Joerg; Guagnano, Vito; Chène, Patrick; Schmelzle, Tobias
• Is Part Of: ChemMedChem. Volume 17:Number 19(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-10-06
• Subjects: TEAD -- YAP -- PPI inhibitors virtual screening -- structure-based design; Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.1002/cmdc.202200514
• Languages: English
• ISSNs: 1860-7179

Abstract

Abstract : The Front Cover shows a representative of the first class of potent disrupters of the YAP‐TEAD interaction in complex with TEAD. This molecule inhibits the transcriptional activity of TEAD, leading to a robust cellular antiproliferative effect. More information can be found in the Research Article by Pascal Furet, Vito Guagnano, Patrick Chène, Tobias Schmelzle, et al.