Drivers of blood use in paediatric trauma: A retrospective cohort study. Issue 5 (14th August 2022)

• Record Type: Journal Article
• Authors: Gebregiorgis, Hermela T.; Hasan, Rida A.; Liu, Zhinan; Phuong, Jim; Stansbury, Lynn G.; Khan, Jenna; Tsang, Hamilton C.; Vavilala, Monica S.; Hess, John R.
• Is Part Of: Transfusion medicine. Volume 32:Issue 5(2022)
• Page Start: 383
• Page End: 393
• Publication Date: 2022-08-14
• Subjects: Blood -- Transfusion -- Periodicals; 615.39
• DOI: 10.1111/tme.12901
• Languages: English
• ISSNs: 0958-7578

Abstract

Abstract: Objectives: We asked whether age or injury severity drives blood use patterns in paediatric trauma. Background: Transfusion for paediatric trauma care is complicated by known developmental differences in coagulation and injury patterns. Methods/Materials: We linked 10 years of Trauma Registry and blood bank data, 2011–2020, for all acute trauma patients aged <18 treated at a large US Level 1 adult and paediatric trauma centre. We assessed age, injury severity and mechanism for association with any blood use, use within the first 4 h of care, and resuscitation balance, using grouped‐age Chi‐square and multivariable regression models. Results: Of 60 066 acute trauma arrivals at our centre in the study period, 7979 (13.3%) met inclusion criteria. Median age (IQR) was (7.6[2.4–14.5]); 6230(78.1%) were < 15 years old; 590(7.4%) received any blood products; and 128(1.6%) died. Among the 5842(73.2%) patients with impact‐related injury, 2023(34.6%) met standards for severe injury (New Injury Severity Score [NISS] ≥ 16); 541(9.3%) were transfused, 171(31.6%) in the first 4 h and 72(13.3%) using ≥3 units of products in the first hour. Firearms injuries were the most severe, most likely to be transfused urgently, using balanced resuscitation, and to die ( p < 0.001 for all). Multivariable logistic regression showed any blood use as strongly associated with NISS (Odds Ratio 1.124832; p < 0.0001; 95% CI 1.11–1.13) but not with age (OR 0.98; p = 0.07; 95% CI 0.96–1.00). Conclusion: Transfusion in the care of acute paediatric trauma is uncommon (<10% of injured minors in our cohorts received any blood products), and injury severity, particularly firearms injury—not age—drove transfusion.