Silver-catalyzed cascade cyclization and functionalization of N-aryl-4-pentenamides: an efficient route to γ-lactam-substituted quinone derivatives. Issue 41 (21st September 2022)

• Record Type: Journal Article
• Authors: Fang, Zeguo; Xie, Lin; Wang, Liang; Zhang, Qian; Li, Dong
• Is Part Of: RSC advances. Volume 12:Issue 41(2022)
• Page Start: 26776
• Page End: 26780
• Publication Date: 2022-09-21
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d2ra05283k
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : The synthesis of γ-lactam and related 2-oxazolidinone substituted quinone derivatives through a Ag2 O-catalyzed cascade cyclization and functionalization of N -ary-4-pentenamides and N -aryl allyl carbamates has been developed. Abstract : The synthesis of γ-lactam-substituted quinone derivatives through a Ag2 O-catalyzed cascade cyclization and functionalization of N -aryl-4-pentenamides has been developed. Related 2-oxazolidinone substituted quinone products can be also obtained with N -aryl allyl carbamates. The reactions proceed through an amidyl radical-initiated 5- exo -trig cyclization and followed radical addition to quinones. They provide an efficient route to various γ-lactam-substituted quinone derivatives with a wide range of substrate scope.