A water-soluble membrane transporter for biologically relevant cations. Issue 43 (29th September 2022)

• Record Type: Journal Article
• Authors: Yang, Kylie; Boles, Jessica E.; White, Lisa J.; Hilton, Kira L. F.; Lai, Hin Yuk; Long, Yifan; Hiscock, Jennifer R.; Haynes, Cally J. E.
• Is Part Of: RSC advances. Volume 12:Issue 43(2022)
• Page Start: 27877
• Page End: 27880
• Publication Date: 2022-09-29
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d2ra05314d
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Synthetic ionophores are promising therapeutic targets, yet poor water solubility limits their potential for translation into the clinic. Here we report a water soluble, supramolecular self-associating amphiphile (SSA) with cation transport function. Abstract : Synthetic ionophores are promising therapeutic targets, yet poor water solubility limits their potential for translation into the clinic. Here we report a water-soluble, supramolecular self-associating amphiphile that functions as a cation uniporter in synthetic vesicle systems, deriving mechanistic insight through planar bilayer patch clamp experiments.