Cover Feature: Silver‐Promoted Fluorination Reactions of α‐Bromoamides (Chem. Eur. J. 19/2021). Issue 19 (28th January 2021)

• Record Type: Journal Article
• Authors: Mizuta, Satoshi; Kitamura, Kanami; Kitagawa, Ayako; Yamaguchi, Tomoko; Ishikawa, Takeshi
• Is Part Of: Chemistry. Volume 27:Issue 19(2021)
• Page Start: 5832
• Page End: 5832
• Publication Date: 2021-01-28
• Subjects: amides -- fluorination -- halogenation -- silver -- synthetic methods; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.202100131
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : Open and shut with silver ! A silver‐promoted fluorine substitution reaction of α‐bromoamide has been recently developed. This methodology enables access to tertiary, secondary, and primary alkyl fluorides with chemoselectivity and stereospecificity by forming an aziridinone intermediate. The cover image depicts that molecules are closed, and opening like an umbrella. In addition, the reaction of α ‐bromoamide with O ‐nucleophiles including OCF3 provided the sterically hindered alcohol, ester and ether. More information can be found in the Full Paper by S. Mizuta et al. on page 5930 .