Cytotoxic Activities of Bis‐cyclometalated Rhodium(III) and Iridium(III) Complexes Containing 2, 2'‐Biphenyldiamine. Issue 5 (8th February 2021)

• Record Type: Journal Article
• Authors: Graf, Marion; Böttcher, Hans‐Christian; Metzler‐Nolte, Nils; Sünkel, Karlheinz; Thavalingam, Sugina; Czerwieniec, Rafał
• Is Part Of: Zeitschrift für anorganische und allgemeine Chemie. Volume 647:Issue 5(2021)
• Page Start: 519
• Page End: 524
• Publication Date: 2021-02-08
• Subjects: 2, 2'-Biphenyldiamine -- Cyclometalated complexes -- Cytotoxic activity -- Iridium -- Rhodium; Chemistry, Inorganic -- Periodicals; Chemistry -- Periodicals; 540
• DOI: 10.1002/zaac.202000460
• Languages: English
• ISSNs: 0044-2313

Abstract

Abstract: The synthesis and characterization of new bis‐cyclometalated complex salts [M(ptpy)2 (2, 2'‐biphenyldiamine)]PF6 (M=Rh, 1 ; M=Ir, 2 ; ptpy=2‐( p ‐tolyl)pyridinato) are described. Compounds 1 and 2 were obtained by bridge‐splitting reactions of [{M(μ‐Cl)(ptpy)2 }2 ] (M=Rh or Ir) with 2, 2'‐biphenyldiamine in CH2 Cl2 /MeOH/H2 O mixtures. The molecular structure of compound 2 in the crystal was confirmed by single‐crystal X‐ray diffraction. 2 crystallized from dichloromethane/methanol/ n ‐heptane in the monoclinic space group P 21 / n . The cytotoxic activities of both new compounds were examined and evaluated. Compound 1 and 2 exhibit significant cytotoxicity against human cancer cell lines with the IC50 values in the low micromolar range. Abstract :