Regio‐ and Diastereoselective Copper‐Catalyzed Carbomagnesiation for the Synthesis of Penta‐ and Hexa‐Substituted Cyclopropanes. (14th April 2021)

• Record Type: Journal Article
• Authors: Cohen, Yair; Augustin, André U.; Levy, Laura; Jones, Peter G.; Werz, Daniel B.; Marek, Ilan
• Is Part Of: Angewandte Chemie. Volume 133:Number 21(2021)
• Page Start: 11910
• Page End: 11914
• Publication Date: 2021-04-14
• Subjects: carbon quaternary stereocenters -- copper-catalyzed carbomagnesiation -- diastereoselectivity -- persubstituted cyclopropanes; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.202102509
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Despite the highly strained nature of cyclopropanes possessing three vicinal quaternary carbon stereocenters, the regio‐ and diastereoselective copper‐catalyzed carbomagnesiation reaction of cyclopropenes provides an easy and efficient access to these novel persubstituted cyclopropyl cores with a complete regio‐ and diastereoselectivity. Abstract : Despite the highly strained nature of cyclopropanes possessing three vicinal quaternary stereocenters, the regio‐ and diastereoselective copper‐catalyzed carbomagnesiation reaction provides an easy and efficient access to these novel persubstituted cyclopropyl cores with a complete regio‐ and diastereoselectivity.