Prevalence of HPV‐16/18 genotypes and immediate histopathologic correlation results in a Chinese population with negative cytology and positive high‐risk HPV testing. Issue 10 (18th September 2019)

• Record Type: Journal Article
• Authors: Tao, Xiang; Zhang, Huina; Li, Juan; Zhang, Hao; Xiao, Jianan; Zhang, Lihong; Zhou, Xianrong; Sui, Long; Wang, Li; Zhao, Chengquan
• Is Part Of: Cancer cytopathology. Volume 127:Issue 10(2019)
• Page Start: 650
• Page End: 657
• Publication Date: 2019-09-18
• Subjects: Chinese -- histopathologic examination -- human papillomavirus 16/18 (HPV‐16/18) -- negative cytology; Cancer -- Cytopathology -- Periodicals; Pathology, Cellular -- Periodicals; Cytology -- Technique -- Periodicals; 611.01815
• DOI: 10.1002/cncy.22180
• Languages: English
• ISSNs: 1934-662X

Abstract

Abstract : Background: The objective of this study was to examine the prevalence of human papillomavirus 16/18 (HPV‐16/18) genotypes and immediate histopathologic correlations in a Chinese population with negative cytology and positive high‐risk human papillomavirus (hrHPV) testing. Methods: Patients who had documented negative cytology with immediate follow‐up (within the 6 months after negative for intraepithelial lesion or malignancy Papanicolaou [Pap] testing), including a histopathologic examination and/or hrHPV testing, between 2011 and 2018 were included, and the data were analyzed. Results: Among 1, 424, 182 Pap tests, 1, 333, 453 (93.6%) were interpreted as negative cytology. Although conventional Pap smears had the highest reporting rate, cervical intraepithelial neoplasia 2 and higher (CIN‐2+) lesions were detected significantly more with liquid‐based cytology preparations (2.1%) than the conventional method (1.4%; P < .01). The overall hrHPV‐positive rate was 14.9% (25, 507 of 171, 273) in the women with negative cytology. Among the 18, 423 cytology‐negative, HPV‐positive cases tested with the Cobas assay, the overall HPV‐16/18 prevalence was 24.7%, with 17.9% being HPV‐16–positive, 6.2% being HPV‐18–positive, and 0.6% being positive for both HPV‐16 and HPV‐18. The immediate histopathologic examination was documented for 21, 796 women with cotesting results, including 8915 HPV‐positive cases and 12, 881 HPV‐negative cases. CIN‐2+ lesions were diagnosed in 15.2% of the HPV‐16–positive cases; this rate was significantly higher than the rates seen in the HPV‐18–positive cases (4.8%) and the cases positive for 1 of the other 12 types of HPV (3.0%). Conclusions: This is by far the largest routine clinical practice report of HPV‐16/18 genotyping and histopathologic examination in negative‐cytology women and the first report of such an investigation in the Chinese population. This study indicates enhanced risk stratification with HPV‐16/18 genotype testing in HPV‐positive, cytology‐negative women in the Chinese population. Abstract : HPV 16/18 positivity accounts for 24.7% of cases positive for HPV with negative cytology. CIN‐2+ lesions are detected significantly more in HPV 16–positive cases.