A CAD System for Hemorrhagic Stroke. Issue 4 (August 2014)

• Record Type: Journal Article
• Authors: Nowinski, Wieslaw L.; Qian, Guoyu; Hanley, Daniel F.
• Is Part Of: Neuroradiology journal. Volume 27:Issue 4(2014)
• Page Start: 409
• Page End: 416
• Publication Date: 2014-08
• Subjects: stroke -- hemorrhagic stroke -- CAD -- hemorrhage -- NCCT -- CLEAR -- MISTIE; Nervous system -- Radiography -- Periodicals; Neuroradiography -- Periodicals; Electronic journals; 616.804757
• DOI: 10.15274/NRJ-2014-10080
• Languages: English
• ISSNs: 1971-4009

Abstract

Computer-aided detection/diagnosis (CAD) is a key component of routine clinical practice, increasingly used for detection, interpretation, quantification and decision support. Despite a critical need, there is no clinically accepted CAD system for stroke yet. Here we introduce a CAD system for hemorrhagic stroke. This CAD system segments, quantifies, and displays hematoma in 2D/3D, and supports evacuation of hemorrhage by thrombolytic treatment monitoring progression and quantifying clot removal. It supports seven-step workflow: select patient, add a new study, process patient's scans, show segmentation results, plot hematoma volumes, show 3D synchronized time series hematomas, and generate report. The system architecture contains four components: library, tools, application with user interface, and hematoma segmentation algorithm. The tools include a contour editor, 3D surface modeler, 3D volume measure, histogramming, hematoma volume plot, and 3D synchronized time-series hematoma display. The CAD system has been designed and implemented in C++. It has also been employed in the CLEAR and MISTIE phase-III, multicenter clinical trials. This stroke CAD system is potentially useful in research and clinical applications, particularly for clinical trials.