A Concise Analytical Profile of Efavirenz: Analytical Methodologies. (3rd October 2022)

• Record Type: Journal Article
• Authors: Ambhore, Jaya P.; Chaudhari, Suraj R.; Cheke, Rameshwar S.; Kharkar, Prashant S.
• Is Part Of: Critical reviews in analytical chemistry. Volume 52:Number 7(2022)
• Page Start: 1583
• Page End: 1592
• Publication Date: 2022-10-03
• Subjects: Analytical methods -- antiretroviral therapy -- efavirenz -- HIV -- pharmaceutical -- matrices; Chemistry, Analytic -- Periodicals; 543
• DOI: 10.1080/10408347.2021.1895711
• Languages: English
• ISSNs: 1040-8347

Abstract

Abstract: Non-nucleoside reverse transcriptase inhibitors are the prime members of antiretroviral therapy that are presently employed for the management of the human immunodeficiency virus. It uses an enzyme i.e., reverse transcriptase to convert its ribonucleic acid into reverse transcription; these agents impede the function of reverse transcriptase and reverse transcription counter human immunodeficiency virus from replicating. Efavirenz is the first-generation non-nucleoside reverse transcriptase inhibitor agent. Similar to the other non-nucleoside reverse transcriptase inhibitor agents; it is prescribed with other inhibitors in combination for regimens antiretroviral therapy. To enhance survival and avoid aggressive infections in patients affected with human immunodeficiency virus infection, adequate antiretroviral therapy is the most significant treatment. Accordingly, the development and validation of such therapeutic agents are challenging work for the analysts. Therefore, the proposed review integrally addresses the analytical reports of efavirenz recorded in the literature databases like Scopus, Web of Science, Google Scholar, Pub-Med, and through many other sources. It has been remarked that for the development of efavirenz many analytical techniques were used for addressing the qualitative and quantitative estimation of efavirenz from various pharmaceutical and biological matrices. This review plan to review the stereochemistry, mechanism of action, resistance, pharmacokinetics, pharmacodynamics, safety and adverse reaction, and various analytical approaches assessed for the same. The hyphenated and chromatographic techniques are frequently used for analysis of cited drug.