Global incidence and risk factors of post-operative sore throat among patients who underwent surgery: A systematic review and meta-analysis. (October 2022)

• Record Type: Journal Article
• Authors: Obsa, Mohammed Suleiman; Adem, Abdi Oumer; Bancha, Bereket; Gelgelu, Temesgen Bati; Gemechu, Ashebir Debalke; Tilla, Mebratu; Nugusse, Mitiku Ayele; Wosene, Naol Gorde; Gobena, Negeso; Hamu, Ahmed; Abdulkadir, Shemseddin
• Is Part Of: International journal of surgery open. Volume 47(2022)
• Publication Date: 2022-10
• Subjects: Postoperative sore throat -- Incidence and risk factors -- Surgical patients; Surgery -- Periodicals; 617.005
• DOI: 10.1016/j.ijso.2022.100536
• Languages: English
• ISSNs: 2405-8572

Abstract

Abstract: Background: Postoperative sore throat is a common, uncomfortable, stressful sequel of tracheal intubation that contributes to postoperative mortality and morbidity following general anesthesia. Therefore, reducing risks of post-operative sore throat is important to improve patient outcome. Objectives: The objective of this systematic review and meta-analysis was to evaluate the incidence and risk factors of postoperative sore throat among patients who underwent surgery. Methods: Studies were retrieved from PubMed, Cochrane Database, Cinahl, Scopus, Mednar, Hinari and Google Scholar by employing a combination of search terms with Boolean operators. Heterogeneity across studies was assessed using the Cochrane Q test. Funnel plot was used for visual assessment of publication bias. Subgroup analyses by country and meta-regression was performed to explore the possible causes of heterogeneity. Egger's weighted regression test at a p-value < 0.05 was used to assess the presence of publication bias. Sensitivity analysis was performed to judge whether the pooled effect size was influenced by individual study. Stata v14.0 (Statacorp, College Station, Texas, USA) software was used for all statistical analyses. STATA software version 14 was used for all statistical analyses. Result: A total of 11 studies with 5885 total sample size were included. The total number of patients who developed Post-operative sore throat was 2252. The pooled prevalence of Post-operative sore throat was 40.48% (95% CI: 35.16, 45.79). The visual inspection of the funnel plot showed the symmetrical distribution. Patients who had number of a single attempts were about 42.5% less likely to develop POST than patients who had multiple intubation attempts (OR: 0.58(0.38–0.88), P = 010, I2: 86.6%. Additionally, duration of tube in place less than 1 h was about 18.7% more likely to develop POST than who were not (OR: 1.19(0.29–4.79), P = 0.028, I2: 0.0%). The other independent predictors of POST were OR: 3.01(0.57–15.84), P = 0.19, I2: 92.3%) and OR: 1.56(0.97–2.58), P = 0.080, I2: 0.0%) respectively. Conclusions: Patients' age and sex, size of ETT and LMA, duration of ETT in trachea, experience of anesthetists', number of attempts, induction agent, and smoking were revealed more common causes of sore throat. The number of attempts and the length of tube in place were both linked to the occurrence of postoperative sore throat. Research Registry: Our unique identifying number is reviewregistry1416. Highlights: Postoperative sore throat is a stressful sequel of tracheal intubation. It contributes to postoperative mortality and morbidity. This usually occurs following general anesthesia.