Correlation between chest CT and RT-PCR testing in India's second COVID-19 wave: a retrospective cohort study. Issue 5 (20th January 2022)

• Record Type: Journal Article
• Authors: Mehta, Vishal; Jyoti, Divya; Guria, Rishi Tuhin; Sharma, Chandra Bhushan
• Is Part Of: BMJ evidence-based medicine. Volume 27:Issue 5(2022)
• Page Start: 305
• Page End: 312
• Publication Date: 2022-01-20
• Subjects: COVID-19 -- internal medicine -- intensive & critical care -- radiology & imaging; Evidence-based medicine -- Periodicals; 616.005
• DOI: 10.1136/bmjebm-2021-111801
• Languages: English
• ISSNs: 2515-446X

Abstract

Abstract : Objectives: To assess the diagnostic accuracy of chest CT in clinically suspected patients with COVID-19 using reverse transcriptase PCR (RT-PCR) as the reference standard and establish the correlation between CT Severity Score (CTSS) and RT-PCR results. Design and setting: Retrospective cohort study. Single-centre tertiary care hospital-based study. Participants: We enrolled 112 clinically suspected patients with COVID-19 between 1 April 2021 and 31 May 2021. Chest CT and RT-PCR tests were performed for all patients at a time interval of no longer than 7 days between the two tests. Patients with prior chronic respiratory illnesses were excluded. The diagnostic performance of chest CT was evaluated using RT-PCR as the reference standard. The CTSS was calculated for all patients with positive chest CT findings, and it was correlated with results of the RT-PCR assay. Main outcome measures: The primary outcome measures were determination of the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy of chest CT using RT-PCR as the standard of reference. The correlation between CTSS and RT-PCR was the secondary outcome. Results: 85/112 (76%) patients tested positive on the RT-PCR whereas 91/112 (81%) had chest CT findings typical of SARS-CoV-2 infection. Chest CT had a sensitivity of 90.6% (95% CI 82.3% to 95.8%), a specificity of 48.1% (95% CI 28.7% to 68.0%), a PPV of 84.6% (95% CI 79.2% to 88.8%), an NPV of 61.9% (95% CI 43.0% to 77.8%) and an accuracy of 80.4% (95% CI 71.8% to 87.3%). There was a significant correlation between the CTSS and RT-PCR positivity (p value=0.003). Conclusion: In our experience, chest CT has a good sensitivity and provides a reliable diagnostic tool for moderate-to-severe COVID-19 cases in resource limited settings.