Imaging timing after glioblastoma surgery (INTERVAL-GB): protocol for a UK and Ireland, multicentre retrospective cohort study. Issue 9 (13th September 2022)

• Record Type: Journal Article
• Authors: Gillespie, Conor S; Bligh, Emily R; Poon, Michael T C; Solomou, Georgios; Islim, Abdurrahman I; Mustafa, Mohammad A; Rominiyi, Ola; Williams, Sophie T; Kalra, Neeraj; Mathew, Ryan K; Booth, Thomas C; Thompson, Gerard; Brennan, Paul M; Jenkinson, Michael D
• Other Names: author non-byline.; Abdullmalek Hidayatul author non-byline.; Abualsaud Suhaib author non-byline.; Adegboyega Gideon author non-byline.; Afulukwe Chinelo author non-byline.; Ahmed Ahmed author non-byline.; Ahmed Najma author non-byline.; Amoo Michael author non-byline.; Al-Sousi Abdelsalam Nedal author non-byline.; Al-Tamimi Yahia author non-byline.; Anand Ajitesh author non-byline.; Bahu Prithvi author non-byline.; Barua Neil author non-byline.; Bhatt Harsh author non-byline.; Bligh Emily R author non-byline.; Bodkin Peter author non-byline.; Boiangiu Ion author non-byline.; Boyle Abbey author non-byline.; Bredell Christiaan author non-byline.; Brennan Paul M author non-byline.; Chaudri Talhah author non-byline.; Cheong Jeremy author non-byline.; Cios Ana author non-byline.; Cleer Iona author non-byline.; Coope David author non-byline.; Coulter Ian author non-byline.; Critchley Giles author non-byline.; Davis Harriet author non-byline.; Luna Paolo Jose De author non-byline.; Dey Nayan author non-byline.; Duric Bea author non-byline.; Egiz Abdullah author non-byline.; Ekert Justyna O author non-byline.; Egu Chinedu Brian author non-byline.; Ekanayake Jinendra author non-byline.; Elso Anna author non-byline.; Ferreira Tomas author non-byline.; Flannery Tom author non-byline.; Fung Kwan Wai author non-byline.; Ganguly Rahul author non-byline.; Gillespie Conor S author non-byline.; Goyal Sanay author non-byline.; Hardman Emily author non-byline.; Harris Lauren author non-byline.; Hirst Theodore author non-byline.; Hoah Kelvin Sunn author non-byline.; Hodgson Sam author non-byline.; Hossain-Ibrahim Kismet author non-byline.; Houlihan Lena Mary author non-byline.; Houssaini Sami Squali author non-byline.; Hoque Sadid author non-byline.; Hutton Dana author non-byline.; Hossain-Ibrahim Kismet author non-byline.; Islim Abdurrahman I author non-byline.; Javed Mahnoor author non-byline.; Jenkinson Michael D author non-byline.; Kalra Neeraj author non-byline.; Kannan Siddarth author non-byline.; Kapasouri Efthymia Maria author non-byline.; Keenlyside Andrew author non-byline.; Kehoe Kristy author non-byline.; Kewlani Bharti author non-byline.; Khanna Prerna author non-byline.; Koning Rosaline de author non-byline.; Kumar Kunalika Sathish author non-byline.; Kuri Ashvin author non-byline.; Lammy Simon author non-byline.; Lee Eunkyung author non-byline.; Magouirk Robert author non-byline.; Martin Andrew J author non-byline.; Masina Riccardo author non-byline.; Mathew Ryan K author non-byline.; Mazzoleni Adele author non-byline.; McAleavey Patrick author non-byline.; McKenna Gráinne author non-byline.; McSweeney Daniel author non-byline.; Moughal Saad author non-byline.; Mustafa Mohammad A author non-byline.; Mthunzi Engelbert author non-byline.; Ton Nu Ngoc Trinh author non-byline.; Nischal Shiva A author non-byline.; O'Sullivan Michael author non-byline.; Park Jay J author non-byline.; Pesic-Smith Jonathan author non-byline.; Peterson Peter author non-byline.; Phang Isaac author non-byline.; Plaha Puneet author non-byline.; Pandit Anand author non-byline.; Pujara Shyam author non-byline.; Richardson George E author non-byline.; Saad Marwa Mohammed Elrasheed author non-byline.; Sangal Shinjan author non-byline.; Shetty Veekshith author non-byline.; Simon Natalie author non-byline.; Spencer Robert author non-byline.; Sun Rosa author non-byline.; Syed Irtiza author non-byline.; Sunny Jesvin Tom author non-byline.; Vasilica Anca-Mihaela author non-byline.; Nazari Armin author non-byline.; O'Flaherty Daniel author non-byline.; Ooi Setthasorn Zhi Yang author non-byline.; Raja Arslan Khaliq author non-byline.; Ramsay Daniele author non-byline.; Reddi Renitha author non-byline.; Richardson Daniel author non-byline.; Roman Elena author non-byline.; Rominiyi Ola author non-byline.; Roy Dorina author non-byline.; Salim Omar author non-byline.; Samkutty Jeremiah author non-byline.; Selvakumar Jashan author non-byline.; Santarius Thomas author non-byline.; Shanbhag Avani author non-byline.; Smith Stuart author non-byline.; Sofela Agbolahan author non-byline.; St George Edward Jerome author non-byline.; Subramanian Preethi author non-byline.; Sundaresan Vaibhav author non-byline.; Sweeney Kieron author non-byline.; Tan Boon Hoe author non-byline.; Turnbull Nicole author non-byline.; Tao Yuewei author non-byline.; Thorne Lewis author non-byline.; Tweedie Rebecca author non-byline.; Tzatzidou Anastasia author non-byline.; Vaqas Babar author non-byline.; Venturini Sara author non-byline.; Whitehouse Kathrin author non-byline.; Whitfield Peter author non-byline.; Wildman Jack author non-byline.; Williams Isabelle author non-byline.; Williams Karl author non-byline.; Wykes Victoria author non-byline.; Ye Tiffany TS author non-byline.; Yap Kelvin Sunn author non-byline.; Yousuff Mahir author non-byline.; Zulfiqar Asaad author non-byline.; Gillespie Conor S author non-byline.; Bligh Emily R author non-byline.; Poon Michael T C author non-byline.; Solomou Georgios author non-byline.; Gough Melissa author non-byline.; Islim Abdurrahman I author non-byline.; Millward Christopher P author non-byline.; Rominiyi Ola author non-byline.; Zakaria Rasheed author non-byline.; Brennan Paul M author non-byline.; Price Stephen J author non-byline.; Watts Colin author non-byline.; Camp Sophie author non-byline.; Booth Thomas C author non-byline.; Thompson Gerard author non-byline.; Mills Samantha J author non-byline.; Waldman Adam author non-byline.; Jenkinson Michael D author non-byline.; author non-byline.; Poon Michael T C author non-byline.; Islim Abdurrahman I author non-byline.; Kolias Angelos author non-byline.; Woodfield Julie author non-byline.; Chari Aswin author non-byline.; Kalra Neeraj author non-byline.; Bandyopadhyay Soham author non-byline.; Borchert Robin author non-byline.; Piper Rory author non-byline.; Fountain Daniel M author non-byline.; author non-byline.; Gillespie Conor S author non-byline.; Bligh Emily R author non-byline.; Bandyopadhyay Soham author non-byline.; Park Jay J author non-byline.; Ooi Setthasorn ZY author non-byline.; Richardson George E author non-byline.; Clynch Abigail author non-byline.; Burton Oliver author non-byline.; Shanbhag Avani author non-byline.; Steinruecke Moritz author non-byline.; Bolton William author non-byline.; Kewlani Bharti author non-byline.; Touzet Alvaro Yanez author non-byline.; Redpath Hannah author non-byline.; Lee Seong Hoon author non-byline.; Egiz Abdullah author non-byline.; Erhabor Joshua author non-byline.; Mantle Orla author non-byline.;
• Is Part Of: BMJ open. Volume 12:Issue 9(2022)
• Publication Date: 2022-09-13
• Subjects: NEUROSURGERY -- Neurological oncology -- Neuroradiology; Medicine -- Research -- Periodicals; 610.72
• DOI: 10.1136/bmjopen-2022-063043
• Languages: English
• ISSNs: 2044-6055

Abstract

Abstract : Introduction: Glioblastoma is the most common malignant primary brain tumour with a median overall survival of 12–15 months (range 6–17 months), even with maximal treatment involving debulking neurosurgery and adjuvant concomitant chemoradiotherapy. The use of postoperative imaging to detect progression is of high importance to clinicians and patients, but currently, the optimal follow-up schedule is yet to be defined. It is also unclear how adhering to National Institute for Health and Care Excellence (NICE) guidelines—which are based on general consensus rather than evidence—affects patient outcomes such as progression-free and overall survival. The primary aim of this study is to assess MRI monitoring practice after surgery for glioblastoma, and to evaluate its association with patient outcomes. Methods and analysis: ImagiNg Timing aftER surgery for glioblastoma: an eVALuation of practice in Great Britain and Ireland is a retrospective multicentre study that will include 450 patients with an operated glioblastoma, treated with any adjuvant therapy regimen in the UK and Ireland. Adult patients ≥18 years diagnosed with glioblastoma and undergoing surgery between 1 August 2018 and 1 February 2019 will be included. Clinical and radiological scanning data will be collected until the date of death or date of last known follow-up. Anonymised data will be uploaded to an online Castor database. Adherence to NICE guidelines and the effect of being concordant with NICE guidelines will be identified using descriptive statistics and Kaplan-Meier survival analysis. Ethics and dissemination: Each participating centre is required to gain local institutional approval for data collection and sharing. Formal ethical approval is not required since this is a service evaluation. Results of the study will be reported through peer-reviewed presentations and articles, and will be disseminated to participating centres, patients and the public.