Asymptomatic syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following duloxetine treatment for pain with depression: Two case reports. Issue 3 (22nd June 2022)

• Record Type: Journal Article
• Authors: Sato, Aoi; Yasui‐Furukori, Norio; Oda, Yumiko; Yang, Misa; Suzuki, Yudai; Shinozaki, Masataka; Shimizu, Taro; Shimoda, Kazutaka
• Is Part Of: Neuropsychopharmacology reports. Volume 42:Issue 3(2022)
• Page Start: 387
• Page End: 390
• Publication Date: 2022-06-22
• Subjects: duloxetine -- orthopedics -- pain -- SIADH -- SNRI; Neuropsychopharmacology -- Periodicals; 615.78
• DOI: 10.1002/npr2.12279
• Languages: English
• ISSNs: 2574-173X

Abstract

Abstract: Background: Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is a common side effect in patients treated with SSRIs and venlafaxine, while there is little information on SIADH in the treatment of duloxetine for pain. Case presentation: The patients were an 83‐year‐old Japanese male and a 71‐year‐old Japanese female. Several years earlier, they complained of pain. Accidentally, blood tests revealed hyponatremia of 110 mmol/L and 108 mmol/L 35 days and 40 days after initiating duloxetine 20 mg/day, respectively. The hyponatremia of both patients recovered after switching from duloxetine to mianserin. Conclusion: We conclude that asymptomatic SIADH was induced by use of duloxetine. Psychiatrists should be aware of this syndrome.