Diagnosis and differential diagnosis of dermatofibrosarcoma protuberans: Utility of high‐resolution dynamic contrast‐enhanced (DCE) MRI. Issue 5 (31st May 2022)

• Record Type: Journal Article
• Authors: Yu, Qiuyu; Zhu, Yueqian; Huang, Renjun; Li, Yan; Song, Linyi; Zhang, Xiaoping; Tang, Mengxiao; Gu, Qinghua; Li, Ping; Zhou, Naihui; Li, Yonggang
• Is Part Of: Skin research and technology. Volume 28:Issue 5(2022)
• Page Start: 651
• Page End: 663
• Publication Date: 2022-05-31
• Subjects: cellular dermatofibroma -- cutaneous tumors -- keloids -- nodular fasciitis -- spindle cell -- time‐signal intensity curve; Skin -- Research -- Periodicals; Skin -- Diseases -- Periodicals; Skin -- Physiology -- Periodicals; 616.5
• DOI: 10.1111/srt.13164
• Languages: English
• ISSNs: 0909-752X

Abstract

Abstract: Background: Dermatofibrosarcoma protuberans (DFSP) is a kind of low‐grade malignant spindle cell neoplasm, the diagnosis, and treatment, which have markedly attracted clinicians' attention for its repeated recurrence. High‐resolution magnetic resonance imaging (HR‐MRI) has shown unique capabilities in diagnosis of various cutaneous tumors. Materials and methods: Data of 29 patients with clinically suspected DFSPs and undergoing dynamic contrast‐enhanced (DCE) HR‐MRI preoperatively were prospectively collected. The HR‐MRI qualitative features were evaluated and compared. The DCE‐associated quantitative parameters and the time‐signal intensity curve (TIC) types were provided using DCE sequences. Results: A total of 7 DFSPs, nine dermatofibromas (DF, including four cases of cellular variant [CDF]), 12 keloids, and one nodular fasciitis were enrolled. DFSP showed the largest major diameter and the deepest depth. Five DFSPs (71.4%) showed ill‐defined margins as well as infiltration of peripheral adipose. All DFSPs showed irregular shape. Most DFSPs presented hyperintensity on T2 WI (71.4%) and iso‐intensity on T1 WI (85.7%). Six cases (85.7%) had significant enhancement, and six cases (85.7%) had homogeneous enhancement. There were significant differences of K trans, Kep, Ve and iAUC values among DFSPs, DFs, and keloids, and DFSP had the highest values for these parameters. Six DFSPs (85.7%) and four CDFs (100%) showed type‐III TICs, while the other lesions showed type‐Ⅰor type‐Ⅱ TICs. Conclusions: DCE‐HR‐MRI could show the growth characteristics of DFSPs, which was of great value for the diagnosis and differential diagnosis of DFSPs and was helpful for the determination of treatment options, thereby to improve the prognosis of patients.