Comparison of the immunogenicity of five COVID‐19 vaccines in Sri Lanka. Issue 2 (9th July 2022)

• Record Type: Journal Article
• Authors: Jeewandara, Chandima; Aberathna, Inoka Sepali; Danasekara, Saubhagya; Gomes, Laksiri; Fernando, Suranga; Guruge, Dinuka; Ranasinghe, Thushali; Gunasekera, Banuri; Kamaladasa, Achala; Kuruppu, Heshan; Somathilake, Gayasha; Jayamali, Jeewantha; Jayathilaka, Deshni; Wijayatilake, Helanka Dinesh Kumara; Pushpakumara, Pradeep Darshana; Harvie, Michael; Nimasha, Thashmi; de Silva, Shiromi Devika Grace; Wijayamuni, Ruwan; Schimanski, Lisa; Rijal, Pramila; Tan, Jack; Townsend, Alain; Ogg, Graham S.; Malavige, Gathsaurie Neelika
• Is Part Of: Immunology. Volume 167:Issue 2(2022)
• Page Start: 263
• Page End: 274
• Publication Date: 2022-07-09
• Subjects: antibodies -- COVID‐19 -- memory -- vaccination; Immunology -- Periodicals
• DOI: 10.1111/imm.13535
• Languages: English
• ISSNs: 0019-2805

Abstract

Abstract: To determine the antibody responses elicited by different vaccines against SARS‐CoV‐2, we compared antibody responses in individuals 3 months post‐vaccination in those who had received different vaccines in Sri Lanka. Abs to the receptor binding domain (RBD) of the ancestral (wild type) virus (WT) as well as to variants of concern (VoCs), and ACE2 blocking Abs, were assessed in individuals vaccinated with Moderna ( n = 225), Sputnik V ( n = 128) or Sputnik light ( n = 184) and the results were compared with previously reported data on Sinopharm and AZD1222 vaccinees. A total of 99.5% of Moderna, >94% of AZD1222 or Sputnik V and >70% of Sputnik light, >60% of Sinopharm vaccine recipients, had a positive response to ACE2 blocking antibodies. The ACE2 blocking antibody levels were highest to lowest was Moderna > Sputnik V/AZD1222 (had equal levels) > Sputnik light > Sinopharm. All Moderna recipients had antibodies to the RBD of WT, alpha and beta, while positivity rates for delta variant was 80%. The positivity rates for Sputnik V vaccinees for the WT and VoCs were higher than for AZD1222 vaccinees while those who received Sinopharm had the lowest positivity rates (<16.7%). The total antibodies to the RBD were highest for the Sputnik V and AZD1222 vaccinees. The Moderna vaccine elicited the highest ACE2 blocking antibody levels followed by Sputnik V/AZD1222, while those who received Sinopharm had the lowest levels. These findings highlight the need for further studies to understand the effects on clinical outcomes. Abstract : We found that the seropositivity rates, ACE2 blocking antibody levels and antibodies to the receptor binding domain of variants of concern showed a significant variation between vaccines. The levels of ACE2 blocking antibodies were the highest for Moderna, followed by Sputnik V and AZD1222, followed by the lowest for Sinopharm. These differences in the antibody response to different vaccines may have significant implications in breakthrough infection rates, hospitalization and severe disease in different vaccine recipients.