NTRK3 mutation in secretory carcinoma of the parotid gland: A Case report. Issue 9 (5th September 2022) - AlKaabba, Fahad
Abstract: Mammary analog secretory carcinoma (MASC) is a newly described carcinoma with a molecular hallmark of ETV6‐NTRK3 fusion that promotes oncogenesis. While MASC histopathology was well‐studied in the literature, clinical behavior remains unstudied. We present a 22‐year‐old man with painless parotid mass, which was diagnosed as salivary gland cancer, MASC subtype. Abstract : MASC is a newly recognized malignant salivary gland tumor that has similar histological and genetic features to BSC. MASC clinical behavior is still lacking in the medical literature. Further research is needed to understand the clinical behavior and the role of NTRK inhibitors in managing locally advanced NTRK‐altered MASC.