The role of the Hippo pathway in heart disease. (12th July 2021)

• Record Type: Journal Article
• Authors: Xie, Jiahong; Wang, Yuxin; Ai, Ding; Yao, Liu; Jiang, Hongfeng
• Is Part Of: FEBS journal. Volume 289:Number 19(2022)
• Page Start: 5819
• Page End: 5833
• Publication Date: 2021-07-12
• Subjects: cardiac hypertrophy -- cardiomyopathy -- coronary artery disease -- heart failure -- Hippo pathway -- myocardial infarction; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pathology, Molecular -- Periodicals; 572
• DOI: 10.1111/febs.16092
• Languages: English
• ISSNs: 1742-464X

Abstract

Abstract : Heart disease, including coronary artery disease, myocardial infarction, heart failure, cardiac hypertrophy, and cardiomyopathies, is the leading causes of death worldwide. The Hippo pathway is a central controller for organ size and tissue growth, which plays a pivotal role in determining cardiomyocytes and nonmyocytes proliferation, regeneration, differentiation, and apoptosis. In this review, we summarize the effects of the Hippo pathway on heart disease and propose potential intervention targets. Especially, we discuss the molecular mechanisms of the Hippo pathway involved in maintaining cardiac homeostasis by regulating cardiomyocytes and nonmyocytes function in the heart. Based on this, we conclude that the Hippo pathway is a promising therapeutic target for cardiovascular therapy, which will bring new perspectives for their treatments. Abstract : Heart diseases are among the leading causes of deaths worldwide. The Hippo pathway is a central controller for organ size and tissue growth. Its role in heart diseases received extensive attention. Here, we summarize recent research on the roles of this pathway in heart diseases and discuss the specific mechanisms. This review aims to provide new targets and strategies for the treatment of heart diseases.