Targeting the Hippo/YAP/TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers. Issue 10 (12th August 2022)

• Record Type: Journal Article
• Authors: Howard, Alexander; Bojko, Jodie; Flynn, Benjamin; Bowen, Sophie; Jungwirth, Ute; Walko, Gernot
• Is Part Of: Experimental dermatology. Volume 31:Issue 10(2022)
• Page Start: 1477
• Page End: 1499
• Publication Date: 2022-08-12
• Subjects: basal cell carcinoma -- epidermis -- Hippo signalling -- melanoma -- skin cancer -- squamous cell carcinoma; Dermatology -- Periodicals; 616.5
• DOI: 10.1111/exd.14655
• Languages: English
• ISSNs: 0906-6705

Abstract

Abstract: Skin cancers are by far the most frequently diagnosed human cancers. The closely related transcriptional co‐regulator proteins YAP and TAZ (WWTR1) have emerged as important drivers of tumour initiation, progression and metastasis in melanoma and non‐melanoma skin cancers. YAP/TAZ serve as an essential signalling hub by integrating signals from multiple upstream pathways. In this review, we summarize the roles of YAP/TAZ in skin physiology and tumorigenesis and discuss recent efforts of therapeutic interventions that target YAP/TAZ in in both preclinical and clinical settings, as well as their prospects for use as skin cancer treatments.