Botulinum toxin injection as a single or combined treatment with non‐cross‐linked high molecular weight and low molecular weight hyaluronic acid gel for neck rejuvenation: A randomized clinical trial. Issue 10 (8th August 2022)

• Record Type: Journal Article
• Authors: Noormohammadpour, Pedram; Ehsani, Amirhooshang; Mahmoudi, Hamidreza; Razavi, Zahra; Balighi, Kamran; Azar, Pedram Molhem; Firooz, Alireza; Jabbari, Asma
• Is Part Of: Dermatologic therapy. Volume 35:Issue 10(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-08-08
• Subjects: botulinum toxin -- neck rejuvenation -- Profhilo gel; Skin -- Diseases -- Periodicals; Dermatology -- Periodicals; 616.5
• DOI: 10.1111/dth.15673
• Languages: English
• ISSNs: 1396-0296

Abstract

Abstract: The unpleasant appearance of the neck through the aging process could burden the psychosocial quality of life, therefore various treatment modalities have been used to rejuvenate the neck. The present study aimed to evaluate the efficacy of botulinum toxin injection as a single or combined treatment with Profhilo gel for neck rejuvenation. Patients with a request for neck rejuvenation meeting the inclusion criteria were randomly divided into two groups. Initial clinical scoring based on Wrinkle Severity Rating Scale (WSRS) and skin biomechanical parameters using a multiadaptor system (MPA) were performed before starting the treatment. Dysport Botox was injected for all of the participants, moreover, in one of the groups (intervention), Profhilo gel was injected after 2 weeks and a follow‐up visit was performed for both groups 3 months later. Patients were evaluated according to the GAIS (global aesthetic improvement scale) by two blind dermatologists and skin biophysical parameters were measured by MPA such as TEWL, hydration, thickness, density, visco‐elasticity, net elasticity, pliability/firmness. In this study, 19 participants in the control (Dysport) and intervention (Dysport + PROFhilo gel) groups were evaluated. Before starting the treatment, the two groups were similar in terms of WSRS scores and biophysical skin parameters. Three months after the treatment, it was observed that Hydration ( p < 0.001) and Thickness of the skin ( p = 0.028) in the intervention group were significantly higher than in the control group. Similarly, the GAIS scores of the intervention group showed significantly better results comparing to the control group ( p < 0.001). Profhilo gel following Dysport Botox can be considered as a safe and more effective treatment of neck aging comparing to Dysport Botox injection alone in patients who are not a candidate for surgery due to any reason.