Can the hyperthermia‐mediated heat shock factor/heat shock protein 70 pathway dampen the cytokine storm during SARS‐CoV‐2 infection?. (9th January 2021)

• Record Type: Journal Article
• Authors: Rébé, Cédric; Ghiringhelli, François; Garrido, Carmen
• Is Part Of: British journal of pharmacology. Volume 179:Number 21(2022)
• Page Start: 4910
• Page End: 4916
• Publication Date: 2021-01-09
• Subjects: Pharmacology -- Periodicals; Chemotherapy -- Periodicals; Drug Therapy -- Periodicals; Pharmacology -- Periodicals; 615.1
• DOI: 10.1111/bph.15343
• Languages: English
• ISSNs: 0007-1188

Abstract

Abstract : Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is a major global public health problem. Infection by this virus involves many pathophysiological processes, such as a "cytokine storm, " that is, very aggressive inflammatory response that offers new perspectives for the management and treatment of patients. Here, we analyse relevant mechanism involved in the hyperthermia‐mediated heat shock factors (HSFs)/heat shock proteins (HSP)70 pathway which may provide a possible treatment tool. LINKED ARTICLES: This article is part of a themed issue on The Pharmacology of COVID‐19. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.21/issuetoc