Case Report about Fatal or Near-Fatal Hypersensitivity Reactions to Cetuximab: Anticetuximab IgE as a Valuable Screening Test. (January 2014)

• Record Type: Journal Article
• Authors: Dupont, Benoît; Mariotte, Delphine; Moldovan, Cristian; Grellard, Jean-Michel; Vergnaud, Marie-Claude; Laroche, Dominique; Gervais, Radj
• Is Part Of: Clinical medicine insights. Oncology. Volume 8(2014)
• Publication Date: 2014-01
• Subjects: hypersensitivity -- anaphylaxis -- cetuximab -- antidrug IgE -- neoplasms; Oncology -- Periodicals; 616.994005
• DOI: 10.4137/CMO.S13897
• Languages: English
• ISSNs: 1179-5549

Abstract

Hypersensitivity reactions are a classic side effect of cetuximab. We report the cases of three patients who developed life-threatening hypersensitivity to cetuximab, which could have been predicted by assessing the concentration of serum anticetuximab immunoglobulin (Ig)E. The anti-cetuximab IgE concentration could be an interesting test to predict which patients are at risk of experiencing severe hypersensitivity reactions to cetuximab.