Impact of Gender in Renal Cell Carcinoma: The Relationship of FABP7 and BRN2 Expression with Overall Survival. (January 2014)

• Record Type: Journal Article
• Authors: Tan, Cheng; Takayama, Tatsuya; Takaoka, Naohisa; Fujita, Hiromi; Miyazaki, Miki; Sugiyama, Takayuki; Ozono, Seiichiro
• Is Part Of: Clinical medicine insights. Oncology. Volume 8(2014)
• Publication Date: 2014-01
• Subjects: BRN2 -- FABP7 -- gender -- overall survival -- renal cell carcinoma; Oncology -- Periodicals; 616.994005
• DOI: 10.4137/CMO.S13684
• Languages: English
• ISSNs: 1179-5549

Abstract

Objective: To investigate the relationship between gender differences in fatty acid-binding protein7 (FABP7) and BRN2 (POU class 3 homeobox 2) expression in renal cell carcinoma (RCC) and the prognosis of patients with RCC. Materials and Methods: immunohistochemical (IHC) staining as well as reverse transcription-polymerase chain reaction (RT-PCR) was performed in renal tissues from 103 patients (83 men, mean age = 63.6 years old; 20 women, mean age = 63.1 years old) underwent radical nephrectomy from January 1, 2001 through December 31, 2010. The probability of overall patient survival was estimated using the Kaplan–Meier method. Results: FABP 7 mRNA expression was more frequent in men ( P = 0.07) while BRN2 protein expression was significantly more frequent in women ( P = 0.029). In particular, FABP7 was expressed in 100% of G1 renal cell carcinoma both in mRNA and protein levels. In women, FABP7 (–) and BRN2 (+) groups had a worse prognosis both in mRNA level ( P = 0.038) and protein level ( P = 0.058). BRN2 was expressed 100% of papillary RCC both in mRNA and protein levels. Conclusions: Our results demonstrated that gender was a key factor in FABP7 and BRN2 expression in RCC, and the combination with FABP7 and BRN2 stratified by gender could be a new potential prognostic factor in patients with RCC.