Multicomponent protocol for the synthesis of substituted methyl 3-(3-hydroxy-4-oxo-4H-chromen-2-yl)propanoates from 3-hydroxy-4H-chromen-4-one. Issue 16 (18th August 2022)

• Record Type: Journal Article
• Authors: Komogortsev, Andrey N.; Melekhina, Valeriya G.; Lichitsky, Boris V.
• Is Part Of: Synthetic communications. Volume 52:Issue 16(2022)
• Page Start: 1664
• Page End: 1671
• Publication Date: 2022-08-18
• Subjects: Carbonyl compounds -- 3-Hydroxy-4H-chromen-4-one -- Meldrum's acid -- multicomponent reaction -- methyl propanoates; Organic compounds -- Synthesis -- Periodicals; Chemistry, Organic; Synthesis; 547.205
• DOI: 10.1080/00397911.2022.2107431
• Languages: English
• ISSNs: 0039-7911

Abstract

Abstract: An efficient one-stage method for the preparation of substituted methyl 3-(3-hydroxy-4-oxo-4 H -chromen-2-yl)propanoates was developed. The suggested approach based on multicomponent reaction of 3-hydroxy-4 H -chromen-4-one with carbonyl compounds and Meldrum's acid. The advantages of this synthesis are readily accessible starting materials, mild reaction conditions, atom economy and easy workup procedure, which can avoid chromatographic purifications. The structures of the obtained compounds were established by 1 H, 13 C-NMR spectroscopy and high-resolution mass spectrometry. Graphical Abstract: UF0001