Behavioural actions of tuberoinfundibular peptide 39 (parathyroid hormone 2). (2nd May 2022)

• Record Type: Journal Article
• Authors: Keller, Dávid; Tsuda, Mumeko C.; Usdin, Ted B.; Dobolyi, Arpád
• Other Names: Eiden Lee guestEditor.; Zhang Limei guestEditor.
• Is Part Of: Journal of neuroendocrinology. Volume 34:Number 9(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-05-02
• Subjects: anxiety -- fear -- hypothalamus -- neuropeptide -- nociception; Neuroendocrinology -- Periodicals; 616.4
• DOI: 10.1111/jne.13130
• Languages: English
• ISSNs: 0953-8194

Abstract

Abstract: Tuberoinfundibular peptide of 39 residues (TIP39) acts via its endogenous class B G‐protein coupled receptorthe parathyroid hormone 2 receptor (PTH2R). Hence, it is also known as parathyroid hormone 2. The peptide is expressed in the brain by a small number of neurons with a highly restricted distribution, which in turn project to a large number of brain regions that contain PTH2R. This peptide neuromodulator system has been extensively investigated over the past 20 years including its behavioural actions, such as its role in the control of nociception, fear and fear incubation, anxiety and depression‐like behaviours, and maternal and social behaviours. It also influences thermoregulation and potentially auditory responses. TIP39 probably exerts direct effect on the neuronal networks controlling these behaviours based on the localization of PTH2R and local TIP39 actions. In addition, TIP39 also affects the secretion of several hypothalamic hormones providing the basis for indirect behavioural actions. Recently developed experimental tools have stimulated further behavioural investigations, and novel results obtained are discussed in this review. Abstract : Parathyroid hormone 2 (PTH2), or tuberoinfundibular peptide of 39 residues, is a neuropeptide synthesized by small groups of neurons in specific parts of the thalamus and pons. PTH2 acts on the parathyroid hormone 2 receptor, which has relatively widespread expression in limbic, hypothalamic, auditory and nociceptive brain regions. Accordingly, PTH2 elicits effects on pain, fear, anxiety, social and maternal behaviours, thermoregulation and auditory responses.