Four new secoiridoids from the stem barks of Syringa reticulata (Bl.) Hara. Issue 19 (21st September 2022)

• Record Type: Journal Article
• Authors: Guo, Shuang; Liu, Yan; Sun, Yan-Ping; Pan, Juan; Guan, Wei; Li, Xiao-Mao; Wang, Si-Yi; Algradi, Adnan Mohammed; Yang, Bing-You; Kuang, Hai-Xue
• Is Part Of: Natural product research. Volume 36:Issue 19(2022)
• Page Start: 4957
• Page End: 4966
• Publication Date: 2022-09-21
• Subjects: Syringa reticulata -- secoiridoids -- cytotoxicity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.1914031
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Four new secoiridoids, syrretoside A (1 ), syrretoside B (2 ), 5 β, 8 β -syrretaglucone C(3 ), 5 β, 8 α -syrretaglucone C (4 ), together with eight known secoiridoids (5 –12 ), were isolated from the stem barks of Syringa reticulata (Bl.) Hara. The structures of isolated compounds were established based on the physical and chemical means, NMR spectroscopy, high-resolution mass spectrometry (HR-ESI-MS), and circular dichroism spectrum (CD), as well as in comparison with the literature. The cytotoxicity of isolated compounds was investigated using CCK8 assay, which showed that these compounds had different degrees of inhibitory effect on two human tumor (MGC803, LN229) cell lines. GRAPHICAL ABSTRACT: UF0001