Contact dermatitis in children caused by diabetes devices. (13th June 2022)

• Record Type: Journal Article
• Authors: Alves da Silva, Catarina; Bregnhøj, Anne; Mowitz, Martin; Bruze, Magnus; Andersen, Klaus Ejner; Sommerlund, Mette
• Is Part Of: Contact dermatitis. Volume 87:Number 5(2022)
• Page Start: 406
• Page End: 413
• Publication Date: 2022-06-13
• Subjects: allergic contact dermatitis -- benzoyl peroxide -- children -- diabetes mellitus -- gas chromatography–mass spectrometry -- glucose sensors -- insulin infusion sets -- irritant contact dermatitis -- isobornyl acrylate -- sesquiterpene lactone mix; Contact dermatitis -- Periodicals; 616.51
• DOI: 10.1111/cod.14166
• Languages: English
• ISSNs: 0105-1873

Abstract

Abstract: Background: Insulin pumps and glucose monitoring devices improve diabetes mellitus control and enhance patients' quality of life. However, a growing number of adverse cutaneous reactions related to the use of these devices have been reported. Objective: To investigate the culprits of localized contact dermatitis in paediatric patients with diabetes caused by insulin pumps and glucose monitoring devices. Methods: Retrospective analysis of 15 paediatric patients patch tested as part of a clinical investigation for skin reactions associated with insulin pumps and glucose monitoring devices. Results: Seven patients had positive patch test reactions to isobornyl acrylate (IBOA) and five had positive reactions to benzoyl peroxide (BP). Positive patch test reactions to materials from the glucose sensor and/or insulin pump were seen in 10 of the 15 patients. Three had positive reactions to adhesive remover wipe from Smith and Nephew Remove and four had reactions to EMLA plaster. Conclusion: A high share of patients showed positive reactions to IBOA and/or their medical devices (insulin pumps or glucose devices). A third of patients showed positive reactions to BP. The presence of additional unidentified allergens cannot be excluded, highlighting the importance of access to a full description of the chemical composition of the devices. Abstract : Paediatric patients with diabetes mellitus type I can have positive patch reactions to their diabetes devices as well as to auxiliary creams and plasters, impacting their choice of device, compliance to treatment and diminishing quality of life. Moreover, cross‐reactivity with other substances can be a recurring problem throughout their lives.